Imaging of metabolites using secondary ion mass spectrometry

Imaging of metabolites using secondary ion mass spectrometry

This article provides an overview of the technique of secondary ion mass spectrometry imaging and highlights some current and future areas of application relevant to the field of metabolomics. The approach benefits from label-free analysis of molecular species up to ~1500 Da with minimal sample prep...

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Veröffentlicht in:Metabolomics 2013-03, Vol.9 (Suppl 1), p.102-109
Hauptverfasser: Armitage, Emily G., Kotze, Helen L., Lockyer, Nicholas P.
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Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Life Sciences
Molecular Medicine
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container_title Metabolomics
container_volume 9
creator Armitage, Emily G.
Kotze, Helen L.
Lockyer, Nicholas P.
description This article provides an overview of the technique of secondary ion mass spectrometry imaging and highlights some current and future areas of application relevant to the field of metabolomics. The approach benefits from label-free analysis of molecular species up to ~1500 Da with minimal sample preparation. Offering the highest spatial resolution of current mass spectrometry imaging methodologies, the technique is well-suited to metabolite imaging in both biological tissue and cells, in both 2D and 3D.
doi_str_mv 10.1007/s11306-012-0477-6
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subjects Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Life Sciences
Molecular Medicine
Original Article
title Imaging of metabolites using secondary ion mass spectrometry
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