NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1[Beta] processing via the NLRP1 inflammasome

Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to molecular triggers such as pathogen-associated or damage-associated molecular patterns, the NLRP1 inflammasome promotes caspase-1-dependent proces...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (8), p.2952
Hauptverfasser:	Levandowski, Cecilia B, Mailloux, Christina M, Ferrara, Tracey M, Gowan, Katherine, Ben, Songtao, Jin, Ying, McFann, Kimberly K, Holland, Paulene J, Fain, Pamela R, Dinarello, Charles A, Spritz, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Haplotypes Immune system Polypeptides Proteins Ribonucleic acid Risk assessment RNA T cell receptors
Online-Zugang:	Volltext
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