High Incidence of Triple-Negative Tumors in Sub-Saharan Africa: A Prospective Study of Breast Cancer Characteristics and Risk Factors in Malian Women Seen in a Bamako University Hospital
Objective: Few studies have been conducted on breast cancer in Sub-Saharan Africa and their results have been suspected to be impaired by artefacts. This prospective study was designed to determine tumor and patient characteristics in Mali with control of each methodological step. These data are nec...
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| Veröffentlicht in: | Oncology 2012-09, Vol.83 (5), p.257-263 |
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| creator | Ly, Madani Antoine, Martine Dembélé, Abdoul Karim Levy, Pierre Rodenas, Anita Touré, Boubacari Ali Badiaga, Youssouf Dembélé, Bakary Kossa Bagayogo, Djénèba Coulibaly Diallo, Yacouba Lazare Koné, Abdramane A. Callard, Patrice Bernaudin, Jean-François Diallo, Dapa Aly |
| description | Objective: Few studies have been conducted on breast cancer in Sub-Saharan Africa and their results have been suspected to be impaired by artefacts. This prospective study was designed to determine tumor and patient characteristics in Mali with control of each methodological step. These data are necessary to define breast cancer treatment guidelines in this country. Methods: Clinical and tumor characteristics and known risk factors were obtained in a consecutive series of 114 patients. Each technical step for the determination of tumor characteristics [histology, TNM, grade, estrogen (ER) and progesterone receptors (PR), HER2, and Ki67] was controlled. Results: Patients had a mean age of 46 years. Most tumors were invasive ductal carcinomas (94%), T3-T4 (90%) with positive nodes (91%), grade III (78%), and ER (61%) and PR (72%) negative. HER2 was overexpressed in 18% of cases. The triple-negative subgroup represented 46%, displaying a particularly aggressive pattern (90% grade III; 88% Ki67 >20%). Conclusion: This study demonstrates the high incidence of aggressive triple-negative tumors in Mali. Apart from a higher prevalence of premenopausal women, no significant difference in risk factors was observed between triple-negative tumors and other tumors. The hormonal therapy systematically prescribed therefore needs to be revised in light of this study. |
| doi_str_mv | 10.1159/000341541 |
| format | Article |
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This prospective study was designed to determine tumor and patient characteristics in Mali with control of each methodological step. These data are necessary to define breast cancer treatment guidelines in this country. Methods: Clinical and tumor characteristics and known risk factors were obtained in a consecutive series of 114 patients. Each technical step for the determination of tumor characteristics [histology, TNM, grade, estrogen (ER) and progesterone receptors (PR), HER2, and Ki67] was controlled. Results: Patients had a mean age of 46 years. Most tumors were invasive ductal carcinomas (94%), T3-T4 (90%) with positive nodes (91%), grade III (78%), and ER (61%) and PR (72%) negative. HER2 was overexpressed in 18% of cases. The triple-negative subgroup represented 46%, displaying a particularly aggressive pattern (90% grade III; 88% Ki67 >20%). Conclusion: This study demonstrates the high incidence of aggressive triple-negative tumors in Mali. Apart from a higher prevalence of premenopausal women, no significant difference in risk factors was observed between triple-negative tumors and other tumors. The hormonal therapy systematically prescribed therefore needs to be revised in light of this study.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000341541</identifier><identifier>PMID: 22964749</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Age Distribution ; Age Factors ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biopsy ; Body Mass Index ; Breast cancer ; Breast Neoplasms - chemistry ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - chemistry ; Carcinoma, Ductal, Breast - epidemiology ; Female ; Gynecology. Andrology. Obstetrics ; Hospitals, University - statistics & numerical data ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Incidence ; Ki-67 Antigen - analysis ; Lymphatic Metastasis ; Mali - epidemiology ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Premenopause ; Prospective Studies ; Receptor, ErbB-2 - analysis ; Receptors, Estrogen - analysis ; Receptors, Progesterone - analysis ; Reducing the Worldwide Burden of Cancer ; Reproductive History ; Risk Factors ; Tumors</subject><ispartof>Oncology, 2012-09, Vol.83 (5), p.257-263</ispartof><rights>2012 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 S. Karger AG, Basel.</rights><rights>Copyright (c) 2012 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-ab01627d198b0bb6007fdb5222c8df309bab70acec7d28eeb6f20ebdda52cc3</citedby><cites>FETCH-LOGICAL-c432t-ab01627d198b0bb6007fdb5222c8df309bab70acec7d28eeb6f20ebdda52cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2431,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26395941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22964749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ly, Madani</creatorcontrib><creatorcontrib>Antoine, Martine</creatorcontrib><creatorcontrib>Dembélé, Abdoul Karim</creatorcontrib><creatorcontrib>Levy, Pierre</creatorcontrib><creatorcontrib>Rodenas, Anita</creatorcontrib><creatorcontrib>Touré, Boubacari Ali</creatorcontrib><creatorcontrib>Badiaga, Youssouf</creatorcontrib><creatorcontrib>Dembélé, Bakary Kossa</creatorcontrib><creatorcontrib>Bagayogo, Djénèba Coulibaly</creatorcontrib><creatorcontrib>Diallo, Yacouba Lazare</creatorcontrib><creatorcontrib>Koné, Abdramane A.</creatorcontrib><creatorcontrib>Callard, Patrice</creatorcontrib><creatorcontrib>Bernaudin, Jean-François</creatorcontrib><creatorcontrib>Diallo, Dapa Aly</creatorcontrib><title>High Incidence of Triple-Negative Tumors in Sub-Saharan Africa: A Prospective Study of Breast Cancer Characteristics and Risk Factors in Malian Women Seen in a Bamako University Hospital</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Objective: Few studies have been conducted on breast cancer in Sub-Saharan Africa and their results have been suspected to be impaired by artefacts. This prospective study was designed to determine tumor and patient characteristics in Mali with control of each methodological step. These data are necessary to define breast cancer treatment guidelines in this country. Methods: Clinical and tumor characteristics and known risk factors were obtained in a consecutive series of 114 patients. Each technical step for the determination of tumor characteristics [histology, TNM, grade, estrogen (ER) and progesterone receptors (PR), HER2, and Ki67] was controlled. Results: Patients had a mean age of 46 years. Most tumors were invasive ductal carcinomas (94%), T3-T4 (90%) with positive nodes (91%), grade III (78%), and ER (61%) and PR (72%) negative. HER2 was overexpressed in 18% of cases. The triple-negative subgroup represented 46%, displaying a particularly aggressive pattern (90% grade III; 88% Ki67 >20%). Conclusion: This study demonstrates the high incidence of aggressive triple-negative tumors in Mali. Apart from a higher prevalence of premenopausal women, no significant difference in risk factors was observed between triple-negative tumors and other tumors. The hormonal therapy systematically prescribed therefore needs to be revised in light of this study.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - chemistry</subject><subject>Carcinoma, Ductal, Breast - epidemiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hospitals, University - statistics & numerical data</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Incidence</subject><subject>Ki-67 Antigen - analysis</subject><subject>Lymphatic Metastasis</subject><subject>Mali - epidemiology</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Premenopause</subject><subject>Prospective Studies</subject><subject>Receptor, ErbB-2 - analysis</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Reducing the Worldwide Burden of Cancer</subject><subject>Reproductive History</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>0030-2414</issn><issn>1423-0232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkV2LEzEUhoMobrd64b1IQAS9GM3XzHS86xbXLqwf2IqXw0lyppvtfNRkZqF_zV9nuh0reOVNAi9PnkPOS8gzzt5ynhbvGGNS8VTxB2TClZAJE1I8JJMYs0Qors7IeQi3EctTlT0mZ0IUmcpVMSG_lm5zQ69a4yy2BmlX0bV3uxqTz7iB3t0hXQ9N5wN1LV0NOlnBDXho6bzyzsB7OqdffRd2aO7ZVT_Y_UFy4RFCTxcQpZ4uDm9Mj96F3plAobX0mwtbehnTUf4Jahe9P7oG4ySMRwyBXkAD245-b6PeB9fv6TKOcz3UT8ijCuqAT8d7SlaXH9aLZXL95ePVYn6dGCVFn4BmPBO55cVMM62zuITK6lQIYWa2kqzQoHMGBk1uxQxRZ5VgqK2FVBgjp-T10brz3c8BQ182Lhisa2ixG0LJRS5ylisp_wMVnEsmIjwlL_9Bb7vBt_EbkZoVszQVLI_UmyNl4oqDx6rcedeA35eclYfmy1PzkX0xGgfdoD2Rf6qOwKsRgGCgrmKJxoW_XCaLtLgXPT9yW_Ab9CdgnPMb9_e_WA</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Ly, Madani</creator><creator>Antoine, Martine</creator><creator>Dembélé, Abdoul Karim</creator><creator>Levy, Pierre</creator><creator>Rodenas, Anita</creator><creator>Touré, Boubacari Ali</creator><creator>Badiaga, Youssouf</creator><creator>Dembélé, Bakary Kossa</creator><creator>Bagayogo, Djénèba Coulibaly</creator><creator>Diallo, Yacouba Lazare</creator><creator>Koné, Abdramane A.</creator><creator>Callard, Patrice</creator><creator>Bernaudin, Jean-François</creator><creator>Diallo, Dapa Aly</creator><general>Karger</general><general>S. 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Andrology. Obstetrics</topic><topic>Hospitals, University - statistics & numerical data</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Incidence</topic><topic>Ki-67 Antigen - analysis</topic><topic>Lymphatic Metastasis</topic><topic>Mali - epidemiology</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Premenopause</topic><topic>Prospective Studies</topic><topic>Receptor, ErbB-2 - analysis</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Reducing the Worldwide Burden of Cancer</topic><topic>Reproductive History</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ly, Madani</creatorcontrib><creatorcontrib>Antoine, Martine</creatorcontrib><creatorcontrib>Dembélé, Abdoul Karim</creatorcontrib><creatorcontrib>Levy, Pierre</creatorcontrib><creatorcontrib>Rodenas, Anita</creatorcontrib><creatorcontrib>Touré, Boubacari Ali</creatorcontrib><creatorcontrib>Badiaga, Youssouf</creatorcontrib><creatorcontrib>Dembélé, Bakary Kossa</creatorcontrib><creatorcontrib>Bagayogo, Djénèba Coulibaly</creatorcontrib><creatorcontrib>Diallo, Yacouba Lazare</creatorcontrib><creatorcontrib>Koné, Abdramane A.</creatorcontrib><creatorcontrib>Callard, Patrice</creatorcontrib><creatorcontrib>Bernaudin, Jean-François</creatorcontrib><creatorcontrib>Diallo, Dapa Aly</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ly, Madani</au><au>Antoine, Martine</au><au>Dembélé, Abdoul Karim</au><au>Levy, Pierre</au><au>Rodenas, Anita</au><au>Touré, Boubacari Ali</au><au>Badiaga, Youssouf</au><au>Dembélé, Bakary Kossa</au><au>Bagayogo, Djénèba Coulibaly</au><au>Diallo, Yacouba Lazare</au><au>Koné, Abdramane A.</au><au>Callard, Patrice</au><au>Bernaudin, Jean-François</au><au>Diallo, Dapa Aly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Incidence of Triple-Negative Tumors in Sub-Saharan Africa: A Prospective Study of Breast Cancer Characteristics and Risk Factors in Malian Women Seen in a Bamako University Hospital</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2012-09</date><risdate>2012</risdate><volume>83</volume><issue>5</issue><spage>257</spage><epage>263</epage><pages>257-263</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><abstract>Objective: Few studies have been conducted on breast cancer in Sub-Saharan Africa and their results have been suspected to be impaired by artefacts. This prospective study was designed to determine tumor and patient characteristics in Mali with control of each methodological step. These data are necessary to define breast cancer treatment guidelines in this country. Methods: Clinical and tumor characteristics and known risk factors were obtained in a consecutive series of 114 patients. Each technical step for the determination of tumor characteristics [histology, TNM, grade, estrogen (ER) and progesterone receptors (PR), HER2, and Ki67] was controlled. Results: Patients had a mean age of 46 years. Most tumors were invasive ductal carcinomas (94%), T3-T4 (90%) with positive nodes (91%), grade III (78%), and ER (61%) and PR (72%) negative. HER2 was overexpressed in 18% of cases. The triple-negative subgroup represented 46%, displaying a particularly aggressive pattern (90% grade III; 88% Ki67 >20%). Conclusion: This study demonstrates the high incidence of aggressive triple-negative tumors in Mali. Apart from a higher prevalence of premenopausal women, no significant difference in risk factors was observed between triple-negative tumors and other tumors. The hormonal therapy systematically prescribed therefore needs to be revised in light of this study.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>22964749</pmid><doi>10.1159/000341541</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology, 2012-09, Vol.83 (5), p.257-263 |
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| language | eng |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adult Age Distribution Age Factors Biological and medical sciences Biomarkers, Tumor - analysis Biopsy Body Mass Index Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - epidemiology Breast Neoplasms - pathology Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - epidemiology Female Gynecology. Andrology. Obstetrics Hospitals, University - statistics & numerical data Humans Immunohistochemistry In Situ Hybridization, Fluorescence Incidence Ki-67 Antigen - analysis Lymphatic Metastasis Mali - epidemiology Mammary gland diseases Medical sciences Middle Aged Neoplasm Grading Neoplasm Staging Premenopause Prospective Studies Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Reducing the Worldwide Burden of Cancer Reproductive History Risk Factors Tumors |
| title | High Incidence of Triple-Negative Tumors in Sub-Saharan Africa: A Prospective Study of Breast Cancer Characteristics and Risk Factors in Malian Women Seen in a Bamako University Hospital |
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