A Herpesvirus Encoded Deubiquitinase Is a Novel Neuroinvasive Determinant: e1000387
The neuroinvasive property of several alpha-herpesviruses underlies an uncommon infectious process that includes the establishment of life-long latent infections in sensory neurons of the peripheral nervous system. Several herpesvirus proteins are required for replication and dissemination within th...
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| Veröffentlicht in: | PLoS pathogens 2009-04, Vol.5 (4) |
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| creator | Lee, Joy I Sollars, Patricia J Baver, Scott B Pickard, Gary E Leelawong, Mindy Smith, Gregory A |
| description | The neuroinvasive property of several alpha-herpesviruses underlies an uncommon infectious process that includes the establishment of life-long latent infections in sensory neurons of the peripheral nervous system. Several herpesvirus proteins are required for replication and dissemination within the nervous system, indicating that exploiting the nervous system as a niche for productive infection requires a specialized set of functions encoded by the virus. Whether initial entry into the nervous system from peripheral tissues also requires specialized viral functions is not known. Here we show that a conserved deubiquitinase domain embedded within a pseudorabies virus structural protein, pUL36, is essential for initial neural invasion, but is subsequently dispensable for transmission within and between neurons of the mammalian nervous system. These findings indicate that the deubiquitinase contributes to neurovirulence by participating in a previously unrecognized initial step in neuroinvasion. |
| doi_str_mv | 10.1371/journal.ppat.1000387 |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cell culture Experiments Health sciences Immunization Microbiology Nervous system Pathogenesis Proteins Viruses |
| title | A Herpesvirus Encoded Deubiquitinase Is a Novel Neuroinvasive Determinant: e1000387 |
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