Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution Pathway: e1000197

Phylogenetic analyses have provided strong evidence that amino acid changes in spike (S) protein of animal and human SARS coronaviruses (SARS-CoVs) during and between two zoonotic transfers (2002/03 and 2003/04) are the result of positive selection. While several studies support that some amino acid...

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Veröffentlicht in:	PLoS pathogens 2008-11, Vol.4 (11)
Hauptverfasser:	Sui, Jianhua, Aird, Daniel R, Tamin, Azaibi, Murakami, Akikazu, Yan, Meiying, Yammanuru, Anuradha, Jing, Huaiqi, Kan, Biao, Liu, Xin, Zhu, Quan, Yuan, Qing-an, Adams, Gregory P, Bellini, William J, Xu, Jianguo, Anderson, Larry J, Marasco, Wayne A
Format:	Artikel
Sprache:	eng
Schlagworte:	Competition Experiments Infections Microbiology Mutagenesis Phylogenetics Proteins Viral infections Viruses
Online-Zugang:	Volltext
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