ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors

ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors

Small molecule heparan sulfate mimetics like (VI) and (X) are synthesized by the Ugi four‐component condensation of mannopyranoside‐derived isocyanides (I) and (VII) with a variety of carboxylic acids, e.g.(II), amines such as (III) and (VIII), and formaldehyde (IV) as the carbonyl component, follow...

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Veröffentlicht in:ChemInform 2013-02, Vol.44 (6), p.no-no
Hauptverfasser: Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W., Ferro, Vito
Format: Artikel
Sprache:eng
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anticancer activity
anticarcinogenic activity
anticarcinogenic activity, anticancer activity
carbohydrates
Heparan sulfate
multicomponent reactions
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container_title ChemInform
container_volume 44
creator Liu, Ligong
Li, Caiping
Cochran, Siska
Feder, Daniel
Guddat, Luke W.
Ferro, Vito
description Small molecule heparan sulfate mimetics like (VI) and (X) are synthesized by the Ugi four‐component condensation of mannopyranoside‐derived isocyanides (I) and (VII) with a variety of carboxylic acids, e.g.(II), amines such as (III) and (VIII), and formaldehyde (IV) as the carbonyl component, followed by sulfonation.
doi_str_mv 10.1002/chin.201306150
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source Wiley Online Library Journals Frontfile Complete
subjects anticancer activity
anticarcinogenic activity
anticarcinogenic activity, anticancer activity
carbohydrates
Heparan sulfate
multicomponent reactions
title ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors
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