ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors

ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors

Small molecule heparan sulfate mimetics like (VI) and (X) are synthesized by the Ugi four‐component condensation of mannopyranoside‐derived isocyanides (I) and (VII) with a variety of carboxylic acids, e.g.(II), amines such as (III) and (VIII), and formaldehyde (IV) as the carbonyl component, follow...

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Veröffentlicht in:ChemInform 2013-02, Vol.44 (6), p.no-no
Hauptverfasser: Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W., Ferro, Vito
Format: Artikel
Sprache:eng
Schlagworte:
anticancer activity
anticarcinogenic activity
anticarcinogenic activity, anticancer activity
carbohydrates
Heparan sulfate
multicomponent reactions
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Zusammenfassung:Small molecule heparan sulfate mimetics like (VI) and (X) are synthesized by the Ugi four‐component condensation of mannopyranoside‐derived isocyanides (I) and (VII) with a variety of carboxylic acids, e.g.(II), amines such as (III) and (VIII), and formaldehyde (IV) as the carbonyl component, followed by sulfonation.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201306150