Atmospheric ultrafine particles promote vascular calcification via the NF-[kappa]B signaling pathway
Exposure to atmospheric fine particulate matter (PM2.5) is a modifiable risk factor of cardiovascular disease. Ultrafine particles (UFP, diameter
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| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 2013-02, Vol.304 (4), p.C362 |
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| container_issue | 4 |
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| container_title | American Journal of Physiology: Cell Physiology |
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| creator | Li, Rongsong Mittelstein, David Kam, Winnie Pakbin, Payam Du, Yunfeng Tintut, Yin Navab, Mohamad Sioutas, Constantinos Hsiai, Tzung |
| description | Exposure to atmospheric fine particulate matter (PM2.5) is a modifiable risk factor of cardiovascular disease. Ultrafine particles (UFP, diameter |
| format | Article |
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Ultrafine particles (UFP, diameter <0.1 ...m), a subfraction of PM2.5, promote vascular oxidative stress and inflammatory responses. Epidemiologic studies suggest that PM exposure promotes vascular calcification. Here, we assessed whether UFP exposure promotes vascular calcification via NF-...B signaling. UFP exposure at 50 ...g/ml increased alkaline phosphatase (ALP) activity by 4.4 ± 0.2-fold on day 3 (n = 3, P < 0.001) and matrix calcification by 3.5 ± 1.7-fold on day 10 (n = 4, P < 0.05) in calcifying vascular cells (CVC), a subpopulation of vascular smooth muscle cells with osteoblastic potential. Treatment of CVC with conditioned media derived from UFP-treated macrophages (UFP-CM) also led to an increase in ALP activities and matrix calcification. Furthermore, both UFP and UFP-CM significantly increased NF-...B activity, and cotreatment with an NF-...B inhibitor, JSH23, attenuated both UFP- and UFP-CM-induced ALP activity and calcification. When low-density lipoprotein receptor-null mice were exposed to UFP at 359.5 ...g/m3 for 10 wk, NF-...B activation and vascular calcification were detected in the regions of aortic roots compared with control filtered air-exposed mice. These findings suggest that UFP promotes vascular calcification via activating NF-...B signaling. 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Ultrafine particles (UFP, diameter <0.1 ...m), a subfraction of PM2.5, promote vascular oxidative stress and inflammatory responses. Epidemiologic studies suggest that PM exposure promotes vascular calcification. Here, we assessed whether UFP exposure promotes vascular calcification via NF-...B signaling. UFP exposure at 50 ...g/ml increased alkaline phosphatase (ALP) activity by 4.4 ± 0.2-fold on day 3 (n = 3, P < 0.001) and matrix calcification by 3.5 ± 1.7-fold on day 10 (n = 4, P < 0.05) in calcifying vascular cells (CVC), a subpopulation of vascular smooth muscle cells with osteoblastic potential. Treatment of CVC with conditioned media derived from UFP-treated macrophages (UFP-CM) also led to an increase in ALP activities and matrix calcification. Furthermore, both UFP and UFP-CM significantly increased NF-...B activity, and cotreatment with an NF-...B inhibitor, JSH23, attenuated both UFP- and UFP-CM-induced ALP activity and calcification. When low-density lipoprotein receptor-null mice were exposed to UFP at 359.5 ...g/m3 for 10 wk, NF-...B activation and vascular calcification were detected in the regions of aortic roots compared with control filtered air-exposed mice. These findings suggest that UFP promotes vascular calcification via activating NF-...B signaling. (ProQuest: ... denotes formulae/symbols omitted.)</description><subject>Airborne particulates</subject><subject>Cardiovascular disease</subject><subject>Epidemiology</subject><subject>Human exposure</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Risk factors</subject><issn>0363-6143</issn><issn>1522-1563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNjMtuwjAQAC3USqSl_7AS50h-kCgcCwL11FNvVYVWxiGbmth4HRB_Tw79gJ7mMjMzUahK61JVtXkShTS1KWu1MnPxwtxLKVe6Xhfi-J7PgWPnElkYfU7Y0uAgYspkvWOIKZxDdnBFtqPHBBa9pZYsZgoDXAkhdw4-9-X3L8aIPxtgOg3oaThNm9zd8L4Qzy16dm9_fBXL_e5r-1FO88voOB_6MKap4YPSTdNovVbS_M96AM0mSHY</recordid><startdate>20130215</startdate><enddate>20130215</enddate><creator>Li, Rongsong</creator><creator>Mittelstein, David</creator><creator>Kam, Winnie</creator><creator>Pakbin, Payam</creator><creator>Du, Yunfeng</creator><creator>Tintut, Yin</creator><creator>Navab, Mohamad</creator><creator>Sioutas, Constantinos</creator><creator>Hsiai, Tzung</creator><general>American Physiological Society</general><scope>7QP</scope><scope>7TS</scope></search><sort><creationdate>20130215</creationdate><title>Atmospheric ultrafine particles promote vascular calcification via the NF-[kappa]B signaling pathway</title><author>Li, Rongsong ; Mittelstein, David ; Kam, Winnie ; Pakbin, Payam ; Du, Yunfeng ; Tintut, Yin ; Navab, Mohamad ; Sioutas, Constantinos ; Hsiai, Tzung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_12888229103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Airborne particulates</topic><topic>Cardiovascular disease</topic><topic>Epidemiology</topic><topic>Human exposure</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rongsong</creatorcontrib><creatorcontrib>Mittelstein, David</creatorcontrib><creatorcontrib>Kam, Winnie</creatorcontrib><creatorcontrib>Pakbin, Payam</creatorcontrib><creatorcontrib>Du, Yunfeng</creatorcontrib><creatorcontrib>Tintut, Yin</creatorcontrib><creatorcontrib>Navab, Mohamad</creatorcontrib><creatorcontrib>Sioutas, Constantinos</creatorcontrib><creatorcontrib>Hsiai, Tzung</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><jtitle>American Journal of Physiology: Cell Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Rongsong</au><au>Mittelstein, David</au><au>Kam, Winnie</au><au>Pakbin, Payam</au><au>Du, Yunfeng</au><au>Tintut, Yin</au><au>Navab, Mohamad</au><au>Sioutas, Constantinos</au><au>Hsiai, Tzung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atmospheric ultrafine particles promote vascular calcification via the NF-[kappa]B signaling pathway</atitle><jtitle>American Journal of Physiology: Cell Physiology</jtitle><date>2013-02-15</date><risdate>2013</risdate><volume>304</volume><issue>4</issue><spage>C362</spage><pages>C362-</pages><issn>0363-6143</issn><eissn>1522-1563</eissn><coden>AJPCDD</coden><abstract>Exposure to atmospheric fine particulate matter (PM2.5) is a modifiable risk factor of cardiovascular disease. Ultrafine particles (UFP, diameter <0.1 ...m), a subfraction of PM2.5, promote vascular oxidative stress and inflammatory responses. Epidemiologic studies suggest that PM exposure promotes vascular calcification. Here, we assessed whether UFP exposure promotes vascular calcification via NF-...B signaling. UFP exposure at 50 ...g/ml increased alkaline phosphatase (ALP) activity by 4.4 ± 0.2-fold on day 3 (n = 3, P < 0.001) and matrix calcification by 3.5 ± 1.7-fold on day 10 (n = 4, P < 0.05) in calcifying vascular cells (CVC), a subpopulation of vascular smooth muscle cells with osteoblastic potential. Treatment of CVC with conditioned media derived from UFP-treated macrophages (UFP-CM) also led to an increase in ALP activities and matrix calcification. Furthermore, both UFP and UFP-CM significantly increased NF-...B activity, and cotreatment with an NF-...B inhibitor, JSH23, attenuated both UFP- and UFP-CM-induced ALP activity and calcification. When low-density lipoprotein receptor-null mice were exposed to UFP at 359.5 ...g/m3 for 10 wk, NF-...B activation and vascular calcification were detected in the regions of aortic roots compared with control filtered air-exposed mice. These findings suggest that UFP promotes vascular calcification via activating NF-...B signaling. (ProQuest: ... denotes formulae/symbols omitted.)</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub></addata></record> |
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| ispartof | American Journal of Physiology: Cell Physiology, 2013-02, Vol.304 (4), p.C362 |
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| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Airborne particulates Cardiovascular disease Epidemiology Human exposure Oxidative stress Proteins Risk factors |
| title | Atmospheric ultrafine particles promote vascular calcification via the NF-[kappa]B signaling pathway |
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