Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: A placebo-controlled, ex vivo, serial placebo-controlled serial crossover study

Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) are often prescribed concurrently in patients with nociceptive pain and cardiovascular comorbidity. NSAIDs and ASA inhibit the same COX-enzymes, and thus may interact. ASA’s cardioprotective antiplatelet effect is e...

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Veröffentlicht in:	European journal of clinical pharmacology 2013-03, Vol.69 (3), p.365-371
Hauptverfasser:	Meek, I. L., Vonkeman, H. E., Kasemier, J., Movig, K. L. L., van de Laar, M. A. F. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Aspirin Aspirin - administration & dosage Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Platelets - drug effects Blood Platelets - enzymology Cross-Over Studies Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - adverse effects Drug Administration Schedule Drug Interactions Female Humans Ibuprofen - adverse effects Male Medical sciences Middle Aged Naproxen - adverse effects Netherlands Nonsteroidal anti-inflammatory drugs Pharmacodynamics Pharmacology. Drug treatments Pharmacology/Toxicology Placebo effect Platelet Aggregation Inhibitors - administration & dosage Platelet Function Tests Prospective Studies Pyridines - adverse effects Risk Assessment Sulfones - adverse effects Thiazines - adverse effects Thiazoles - adverse effects Time Factors Young Adult
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