Suppression of hemopoiesis during CCl4-induced hepatic fibrosis: Role of systemic endotoxemia

Suppression of hemopoiesis during CCl4-induced hepatic fibrosis: Role of systemic endotoxemia

CCl^sub 4^-induced hepatic fibrosis in mice was accompanied by insufficiency of bone marrow myelo- and erythropoiesis. Polymyxin B completely abolished these changes. This phenomenon can be explained by the development of macrophage endotoxin tolerance during hepatic fibrosis.[PUBLICATION ABSTRACT]

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Veröffentlicht in:Bulletin of experimental biology and medicine 2000-08, Vol.130 (2), p.759-762
Hauptverfasser: Shvarts, Ya. Sh, Zubakhin, A. A., Dushkin, M. I.
Format: Artikel
Sprache:eng
Schlagworte:
Liver cirrhosis
Rodents
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Zusammenfassung:CCl^sub 4^-induced hepatic fibrosis in mice was accompanied by insufficiency of bone marrow myelo- and erythropoiesis. Polymyxin B completely abolished these changes. This phenomenon can be explained by the development of macrophage endotoxin tolerance during hepatic fibrosis.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02681938