Kinetics of hematopoietic clones in reconstituted mice

Kinetics of hematopoietic clones in reconstituted mice

In mice reconstituted with genetically marked bone marrow, hematopoiesis is shown to be effected, over a period of 14 months after transplantation, by numerous locally existing and short-lived cell clones that succeed one another as the potential of the clonogenic precursor cell is depleted. In each...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1997-02, Vol.123 (2), p.155-158
Hauptverfasser: Drize, N. I., Sadovnikova, E. Yu, Olovnikova, N. I., Belkina, E. V., Nikolaeva, T. L., Chertkov, I. L.
Format: Artikel
Sprache:eng
Schlagworte:
Bone marrow
Cloning
Stem cells
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Zusammenfassung:In mice reconstituted with genetically marked bone marrow, hematopoiesis is shown to be effected, over a period of 14 months after transplantation, by numerous locally existing and short-lived cell clones that succeed one another as the potential of the clonogenic precursor cell is depleted. In each reconstituted mouse, several dozens of hematopoietic clones are functional in the bone marrow. Immortal self-maintaining stem cells with unlimited proliferative potential are not detected in this system.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02766439