Pharmacokinetic evaluation of co-administration of nefazodone and lithium in healthy subjects

To evaluate the possible pharmacokinetic interaction between nefazodone and lithium. Twelve healthy volunteers received nefazodone 200 mg b.i.d. for 5 days. A 4-day washout phase followed from day 6 to day 9. From day 10 to day 20, escalating doses of lithium 250 mg b.i.d. to 500 mg b.i.d. were give...

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