JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

Age-related macular degeneration (AMD) is the leading cause of registered blindness among the elderly and affects over 30 million people worldwide. It is well established that oxidative stress, inflammation, and apoptosis play critical roles in pathogenesis of AMD. In advanced wet AMD, although, mos...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (6), p.2377-2382
Hauptverfasser:	Du, Hongjun, Sun, Xufang, Guma, Monica, Luo, Jing, Ouyang, Hong, Zhang, Xiaohui, Zeng, Jing, Quach, John, Nguyen, Duy H., Shaw, Peter X., Karin, Michael, Zhang, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Angiogenesis Animals Antibodies Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological Sciences Choroidal Neovascularization - drug therapy Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Choroidal Neovascularization - prevention & control Cysteine Proteinase Inhibitors - pharmacology Cytokines - metabolism Disease Models, Animal Gene expression Humans Inflammation Inflammation Mediators - metabolism Lasers Macrophages Macrophages - pathology Macular degeneration Macular Degeneration - drug therapy Macular Degeneration - metabolism Macular Degeneration - pathology Macular Degeneration - prevention & control Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - deficiency Mitogen-Activated Protein Kinase 8 - genetics Oxidative Stress Retina Rodents Vascular Endothelial Growth Factor A - biosynthesis
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