Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers

Although many of the frequently used pluripotency biomarkers are glycoconjugates, a glycoconjugate-based exploration of novel cellular biomarkers has proven difficult due to technical difficulties. This study reports a unique approach for the systematic overview of all major classes of oligosacchari...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (6), p.2105-2110
Hauptverfasser:	Fujitani, Naoki, Furukawa, Jun-ichi, Araki, Kayo, Fujioka, Tsuyoshi, Takegawa, Yasuhiro, Piao, Jinhua, Nishioka, Taiki, Tamura, Tomohiro, Nikaido, Toshio, Ito, Makoto, Nakamura, Yukio, Shinohara, Yasuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological markers Biological Sciences Biomarkers Biomarkers - chemistry Biomarkers - metabolism Caco 2 cells Carbohydrate Metabolism Cell Line Cell Line, Tumor Cell lines Chromatography, High Pressure Liquid Cricetinae Embryonic stem cells Embryonic Stem Cells - metabolism Glycomics - methods glycoproteins glycosaminoglycans glycosphingolipids Glycosylation HEK293 cells Hepatocytes Humans induced pluripotent stem cells Induced Pluripotent Stem Cells - metabolism Kidney cells Lipids Mass spectrometry Metabolome Molecular Structure neoplasm cells oligosaccharides Oligosaccharides - chemistry Oligosaccharides - metabolism Pluripotent stem cells Polysaccharides Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stem cells
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