Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity
Background Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA pa...
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| Veröffentlicht in: | Journal of clinical immunology 2013, Vol.33 (1), p.297-301 |
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| creator | Gheita, Tamer A. El-Gazzar, Iman I. El Shazly, Reem I. El-Din, Abeer M. Nour Abdel-Rasheed, Enas Bassyouni, Rasha H. |
| description | Background
Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA patients and compare its levels according to the categories, clinical manifestations and disease activity.
Methods
Sixty-eight JIA patients and 33 age and sex matched control children were included in the present study. All patients included in this study were subjected to full history taking, clinical examination. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated and Childhood Health Assessment Questionnaire (CHAQ) was used to measure the functional status. Serum resistin levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results
The mean serum resistin was significantly higher in the JIA patients (4.01 ± 2.46 ng/ml) compared to the control (2.08 ± 1.23 ng/ml) (
p
|
| doi_str_mv | 10.1007/s10875-012-9760-6 |
| format | Article |
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Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA patients and compare its levels according to the categories, clinical manifestations and disease activity.
Methods
Sixty-eight JIA patients and 33 age and sex matched control children were included in the present study. All patients included in this study were subjected to full history taking, clinical examination. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated and Childhood Health Assessment Questionnaire (CHAQ) was used to measure the functional status. Serum resistin levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results
The mean serum resistin was significantly higher in the JIA patients (4.01 ± 2.46 ng/ml) compared to the control (2.08 ± 1.23 ng/ml) (
p
< 0.001) especially those with systemic-onset. Its level was significantly higher in those receiving steroids and those with a positive antinuclear antibody. Resistin significantly correlated with the JADAS27 (r 0.26, p 0.035) and CHAQ (r 0.4, p 0.001). The JIA patients were 50 females and 18 males; however, the level of resistin was insignificantly different according to the gender although there was a tendency to be higher in females.
Conclusion
Our results reinforce the proposition of an important role for resistin in JIA and may be considered an interesting biomarker for disease activity especially those with systemic onset.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>DOI: 10.1007/s10875-012-9760-6</identifier><identifier>CODEN: JCIMDO</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Brief Communication ; Immunology ; Infectious Diseases ; Internal Medicine ; Medical Microbiology</subject><ispartof>Journal of clinical immunology, 2013, Vol.33 (1), p.297-301</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c246t-6b89eb763d70706ef935c8838ed8518aa53f8966cc1457935bc489ef4106ee913</citedby><cites>FETCH-LOGICAL-c246t-6b89eb763d70706ef935c8838ed8518aa53f8966cc1457935bc489ef4106ee913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10875-012-9760-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10875-012-9760-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Gheita, Tamer A.</creatorcontrib><creatorcontrib>El-Gazzar, Iman I.</creatorcontrib><creatorcontrib>El Shazly, Reem I.</creatorcontrib><creatorcontrib>El-Din, Abeer M. Nour</creatorcontrib><creatorcontrib>Abdel-Rasheed, Enas</creatorcontrib><creatorcontrib>Bassyouni, Rasha H.</creatorcontrib><title>Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity</title><title>Journal of clinical immunology</title><addtitle>J Clin Immunol</addtitle><description>Background
Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA patients and compare its levels according to the categories, clinical manifestations and disease activity.
Methods
Sixty-eight JIA patients and 33 age and sex matched control children were included in the present study. All patients included in this study were subjected to full history taking, clinical examination. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated and Childhood Health Assessment Questionnaire (CHAQ) was used to measure the functional status. Serum resistin levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results
The mean serum resistin was significantly higher in the JIA patients (4.01 ± 2.46 ng/ml) compared to the control (2.08 ± 1.23 ng/ml) (
p
< 0.001) especially those with systemic-onset. Its level was significantly higher in those receiving steroids and those with a positive antinuclear antibody. Resistin significantly correlated with the JADAS27 (r 0.26, p 0.035) and CHAQ (r 0.4, p 0.001). The JIA patients were 50 females and 18 males; however, the level of resistin was insignificantly different according to the gender although there was a tendency to be higher in females.
Conclusion
Our results reinforce the proposition of an important role for resistin in JIA and may be considered an interesting biomarker for disease activity especially those with systemic onset.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Communication</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><issn>0271-9142</issn><issn>1573-2592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtKAzEUhoMoWKsP4C7gejSXyWXclVpvFAQv65BmzrQp05mapIW-vSnjwo1w4CzO9_8HPoSuKbmlhKi7SIlWoiCUFZWSpJAnaESF4gUTFTtFI8IULSpasnN0EeOaEMIlEyNUz1rY2wQ1_oCw2-B3iD4m3-E8r7s9dL4F_FL7fmvTyrtJSKvgk4_3mWxt8n2HU4-nuWHZBw8R267GDz6CjYAnLvm9T4dLdNbYNsLV7x6jr8fZ5_S5mL89vUwn88KxUqZCLnQFCyV5rYgiEpqKC6c111BrQbW1gje6ktI5WgqVjwtX5kRT0gxDRfkY3Qy929B_7yAms-53ocsvDWVKM0Z5pTNFB8qFPsYAjdkGv7HhYCgxR5lmkGmyTHOUaWTOsCETM9stIfxp_jf0A1Apd0s</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Gheita, Tamer A.</creator><creator>El-Gazzar, Iman I.</creator><creator>El Shazly, Reem I.</creator><creator>El-Din, Abeer M. Nour</creator><creator>Abdel-Rasheed, Enas</creator><creator>Bassyouni, Rasha H.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2013</creationdate><title>Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity</title><author>Gheita, Tamer A. ; El-Gazzar, Iman I. ; El Shazly, Reem I. ; El-Din, Abeer M. Nour ; Abdel-Rasheed, Enas ; Bassyouni, Rasha H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-6b89eb763d70706ef935c8838ed8518aa53f8966cc1457935bc489ef4106ee913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brief Communication</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Medical Microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gheita, Tamer A.</creatorcontrib><creatorcontrib>El-Gazzar, Iman I.</creatorcontrib><creatorcontrib>El Shazly, Reem I.</creatorcontrib><creatorcontrib>El-Din, Abeer M. Nour</creatorcontrib><creatorcontrib>Abdel-Rasheed, Enas</creatorcontrib><creatorcontrib>Bassyouni, Rasha H.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gheita, Tamer A.</au><au>El-Gazzar, Iman I.</au><au>El Shazly, Reem I.</au><au>El-Din, Abeer M. Nour</au><au>Abdel-Rasheed, Enas</au><au>Bassyouni, Rasha H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity</atitle><jtitle>Journal of clinical immunology</jtitle><stitle>J Clin Immunol</stitle><date>2013</date><risdate>2013</risdate><volume>33</volume><issue>1</issue><spage>297</spage><epage>301</epage><pages>297-301</pages><issn>0271-9142</issn><eissn>1573-2592</eissn><coden>JCIMDO</coden><abstract>Background
Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA patients and compare its levels according to the categories, clinical manifestations and disease activity.
Methods
Sixty-eight JIA patients and 33 age and sex matched control children were included in the present study. All patients included in this study were subjected to full history taking, clinical examination. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated and Childhood Health Assessment Questionnaire (CHAQ) was used to measure the functional status. Serum resistin levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results
The mean serum resistin was significantly higher in the JIA patients (4.01 ± 2.46 ng/ml) compared to the control (2.08 ± 1.23 ng/ml) (
p
< 0.001) especially those with systemic-onset. Its level was significantly higher in those receiving steroids and those with a positive antinuclear antibody. Resistin significantly correlated with the JADAS27 (r 0.26, p 0.035) and CHAQ (r 0.4, p 0.001). The JIA patients were 50 females and 18 males; however, the level of resistin was insignificantly different according to the gender although there was a tendency to be higher in females.
Conclusion
Our results reinforce the proposition of an important role for resistin in JIA and may be considered an interesting biomarker for disease activity especially those with systemic onset.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s10875-012-9760-6</doi><tpages>5</tpages></addata></record> |
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| title | Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity |
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