LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in the world, and the development of new therapeutic targets is needed. Recent studies have shown that aerobic glycolysis, also known as the Warburg effect, mediated the anti-apoptotic effects in cancer cells. Lactate...

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Veröffentlicht in:	Tumor biology 2013-02, Vol.34 (1), p.25-31
Hauptverfasser:	Yao, Feng, Zhao, Tiejun, Zhong, Chenxi, Zhu, Ji, Zhao, Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis - genetics Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Caspase 8 - metabolism Cell Cycle - genetics Cell Line, Tumor Cell Movement Cell Proliferation Cell Transformation, Neoplastic - genetics Cellular biology Cyclin D1 - biosynthesis Enzyme Activation Esophageal Neoplasms - enzymology Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Esophagus Female Glycolysis Humans Isoenzymes - genetics Isoenzymes - metabolism L-Lactate Dehydrogenase - genetics L-Lactate Dehydrogenase - metabolism Male Middle Aged Pathogenesis Poly(ADP-ribose) Polymerases - metabolism Proteins Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - metabolism Research Article RNA Interference RNA, Small Interfering Signal Transduction Up-Regulation
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