C1-Symmetric Bicyclo[2.2.2]octa-2,5-diene (bod) Ligands in Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Enones and 1,2-Addition to N-[(4-Nitrophenyl)sulfonyl]imines

A set of ten C1‐symmetric chiral bicyclo[2.2.2]octa‐2,5‐dienes (bod*) 2 (Fig. 1) were tested as ligands in Rh‐catalyzed arylation reactions. The 1,4‐addition of arylboronic acids to cyclohex‐2‐en‐1‐one, cyclopent‐2‐en‐1‐one, and tert‐butyl cinnamate proceeded smoothly with excellent enantioselectivi...

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Veröffentlicht in:	Helvetica chimica acta 2012-10, Vol.95 (10), p.1809-1817
Hauptverfasser:	Brönnimann, Rebecca, Chun, Sothys, Marti, Roger, Abele, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	5-dienes Acids Addition reactions Arylation Bicyclo[2.2.2]octa-2 Bicyclo[2.2.2]octa‐2,5‐dienes Catalysis Enantioselective reaction Ligands Rhodium complexes
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