ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia

The molecular etiology of human progenitor reprogramming into self-renewing leukemia stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered spliceosome gene mutations that promote alternative splicing and portend leukemic transformation, isoform diversity also may be generated...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (3), p.1041-1046
Hauptverfasser:	Jiang, Qingfei, Crews, Leslie A., Barrett, Christian L., Chun, Hye-Jung, Court, Angela C., Isquith, Jane M., Zipeto, Maria A., Goff, Daniel J., Minden, Mark, Sadarangani, Anil, Rusert, Jessica M., Dao, Kim-Hien T., Morris, Sheldon R., Goldstein, Lawrence S. B., Marra, Marco A., Frazer, Kelly A., Jamieson, Catriona H. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine deaminase Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Alternative Splicing Animals Biological Sciences Blast Crisis - etiology Blast Crisis - genetics Blast Crisis - metabolism Blast Crisis - pathology Cell Transformation, Neoplastic Cells Chronic myeloid leukemia Cord blood Disease Progression Enzymes etiology Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene expression Gene Knockdown Techniques gene overexpression Genes Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Inflammation Mediators - metabolism interferon-gamma Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myeloid, Chronic-Phase - genetics Leukemia, Myeloid, Chronic-Phase - metabolism Leukemia, Myeloid, Chronic-Phase - pathology Mice Mutation myeloid leukemia Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Progenitor cells Protein isoforms Ribonucleic acid RNA RNA Editing RNA-Binding Proteins sequence analysis spliceosomes Stem cells tau-protein kinase transcription factors Transcriptome Transplantation, Heterologous Tumor Stem Cell Assay Up regulation
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