Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR

The quorum-sensing regulator PlcR is the master regulator of most known virulence factors in Bacillus cereus . It is a helix-turn-helix (HTH)-type transcription factor activated upon binding of its cognate signaling peptide PapR on a tetratricopeptide repeat-type regulatory domain. The structural an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (3), p.1047-1052
Hauptverfasser:	Grenha, Rosa, Slamti, Leyla, Nicaise, Magali, Refes, Yacine, Lereclus, Didier, Nessler, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural sciences Amino Acid Sequence Apoproteins - chemistry Apoproteins - genetics Apoproteins - metabolism Atoms Bacillus cereus Bacillus cereus - genetics Bacillus cereus - metabolism Bacillus thuringiensis - genetics Bacillus thuringiensis - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Binding Sites Biological Sciences Biosensors Crystallography, X-Ray Dimers DNA DNA, Bacterial - chemistry DNA, Bacterial - genetics Gene expression regulation Genes Genes, Bacterial Gram-positive bacteria Life Sciences Models, Molecular Molecular Sequence Data Mutagenesis Peptides Promoter Regions, Genetic Protein Conformation Protein Interaction Domains and Motifs Protein Multimerization Proteins Quorum Sensing Regulator genes Sequence Homology, Amino Acid Static Electricity Surface areas Trans-Activators - chemistry Trans-Activators - genetics Trans-Activators - metabolism Virulence
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