Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer

The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation in mammals, has been observed in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers. However, the pathological role and the regulatory mechanism of FUT8 in cancers remain l...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (2), p.630-635
Hauptverfasser:	Chen, Chien-Yu, Jan, Yi-Hua, Juan, Yi-Hsiu, Yang, Chih-Jen, Huang, Ming-Shyan, Yu, Chong-Jen, Yang, Pan-Chyr, Hsiao, Michael, Hsu, Tsui-Ling, Wong, Chi-Huey
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion animal ovaries Animals beta Catenin - metabolism Biological Sciences Cadherins Cancer Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell adhesion & migration Cell growth Cell Line, Tumor Cell lines Cell Proliferation colorectal neoplasms Enzymes Epithelial cells Epithelial-Mesenchymal Transition - physiology Female Fucosyltransferases - genetics Fucosyltransferases - metabolism Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques genes Humans liver Lung - metabolism Lung - pathology Lung cancer Lung neoplasms Lungs Lymphoid Enhancer-Binding Factor 1 - metabolism mammals Metastasis Mice Mice, Inbred NOD Mice, SCID Microarray Analysis microarray technology Models, Biological Neoplasm Invasiveness - physiopathology Neoplasm Metastasis - physiopathology patients prognosis receptors relapse surface antigens Survival analysis therapeutics transcriptional activation Transplantation, Heterologous Tumors Up regulation
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