ChemInform Abstract: Synthesis and Structure-Activity Relationship of 1- and 2-Substituted 1,2,3-Triazole Letrozole-Based Analogues as Aromatase Inhibitors

ChemInform Abstract: Synthesis and Structure-Activity Relationship of 1- and 2-Substituted 1,2,3-Triazole Letrozole-Based Analogues as Aromatase Inhibitors

1,2,3‐Triazole analogues, e.g. (III) and (V), of letrozole are synthesized by employing the “click” chemistry as the key step.

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Veröffentlicht in:ChemInform 2012-01, Vol.43 (5), p.no-no
Hauptverfasser: Doiron, Jeremie, Soultan, Al Haliffa, Richard, Ryan, Toure, Mamadou Mansour, Picot, Nadia, Richard, Remi, Cuperlovic-Culf, Miroslava, Robichaud, Gilles A., Touaibia, Mohamed
Format: Artikel
Sprache:eng
Schlagworte:
cycloaddition reactions
enzyme inhibiting activity
triazole derivatives
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Beschreibung
Zusammenfassung:1,2,3‐Triazole analogues, e.g. (III) and (V), of letrozole are synthesized by employing the “click” chemistry as the key step.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201205151