Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample
The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility. Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the bioactivation and detoxification of tobacco carcinogens an...
Gespeichert in:
| Veröffentlicht in: | The Egyptian journal of medical human genetics 2012-10, Vol.13 (3), p.307-312 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 312 |
|---|---|
| container_issue | 3 |
| container_start_page | 307 |
| container_title | The Egyptian journal of medical human genetics |
| container_volume | 13 |
| creator | Fatma, B’chir Aida, Taieb Maurice, J. Arnaud Saguem, Saad |
| description | The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility. Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the bioactivation and detoxification of tobacco carcinogens and may therefore affect lung cancer risk.
In order to assess association between lung cancer and GSTT1, GSTM1 and CYP1A2-2467T/delT, variant allele (CYP1A2*1D) polymorphisms, a case–control study of healthy and smoking lung cancer patients in Tunisian population was conducted. Polymorphisms of GSTs were assayed by multiplex PCR. Genotype polymorphism of CYP1A2*1D was determined by PCR-RFLP assay. Odds Ratio was used for analysing results.
There was no association with any increase of lung cancer risk in GSTT1 null genotype [OR: 0.83 (0.47–1.45)] as well as in GSTM1 null genotype [OR: 0.78 (0.37–1.62)]. However, a significant association between lung cancer and the homozygous mutate variant of the CYP1A2 [(OR=4.7 (1.55–29.78)] was observed.
These results demonstrated that the strong and significant association between CYP1A2*1D and lung cancer appears to be relevant in this Tunisian population, suggesting that CYP1A2 metabolic genetic factor may, in partly, play a role in modulating lung cancer susceptibility. |
| doi_str_mv | 10.1016/j.ejmhg.2012.05.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1266357133</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1110863012000419</els_id><sourcerecordid>2856957431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3131-bced3db8305c53e5510c6d0c5946dae79e1b054adb9fd74b62aa7b197981a1d73</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EEkvhCRCSJa4k9cSxszlwqFalrVQEEuHAyXLsSdfBcYKdIFW8PG634sjJh_n-fzwfIW-BlcBAno8ljtPxrqwYVCUTJWPwjOwq1rKiqmt4TnYAwIq95OwleZXSyJgUvKl35M-V31a9Ht0ckH4r1qhDGjDqhPQzUB0s7eADPfz4ChdV7pJNd27Rd3SZ_f00x-Xo0pQeuTAHmibtfWHQe-q3cEeNDgYjjS79pC7QbgsuOZ05PS0eX5MXg_YJ3zy9Z-T7p8vucF3cfrm6OVzcFoYDh6I3aLnt95wJIzgKAcxIy4xoa2k1Ni1Cz0Stbd8Otql7WWnd9NA27R402Iafkfen3iXOvzZMqxrnLYa8UkElJRcNcJ4pfqJMnFOKOKgluknHewVMPVhWo3q0rB4sKyZUtpxT704pzCgO-l8of53VMs8_Ps3zgb8dRpWMw2zFuohmVXZ2_-3_C8Dlj0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1266357133</pqid></control><display><type>article</type><title>Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample</title><source>African Journals Online (Open Access)</source><source>DOAJ Directory of Open Access Journals</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Fatma, B’chir ; Aida, Taieb ; Maurice, J. Arnaud ; Saguem, Saad</creator><creatorcontrib>Fatma, B’chir ; Aida, Taieb ; Maurice, J. Arnaud ; Saguem, Saad</creatorcontrib><description>The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility. Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the bioactivation and detoxification of tobacco carcinogens and may therefore affect lung cancer risk.
In order to assess association between lung cancer and GSTT1, GSTM1 and CYP1A2-2467T/delT, variant allele (CYP1A2*1D) polymorphisms, a case–control study of healthy and smoking lung cancer patients in Tunisian population was conducted. Polymorphisms of GSTs were assayed by multiplex PCR. Genotype polymorphism of CYP1A2*1D was determined by PCR-RFLP assay. Odds Ratio was used for analysing results.
There was no association with any increase of lung cancer risk in GSTT1 null genotype [OR: 0.83 (0.47–1.45)] as well as in GSTM1 null genotype [OR: 0.78 (0.37–1.62)]. However, a significant association between lung cancer and the homozygous mutate variant of the CYP1A2 [(OR=4.7 (1.55–29.78)] was observed.
These results demonstrated that the strong and significant association between CYP1A2*1D and lung cancer appears to be relevant in this Tunisian population, suggesting that CYP1A2 metabolic genetic factor may, in partly, play a role in modulating lung cancer susceptibility.</description><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1016/j.ejmhg.2012.05.001</identifier><language>eng</language><publisher>Cairo, Egypt: Elsevier B.V</publisher><subject>Cancer ; CYP1A2 ; Glutathione ; GSTT1 ; GSTTM1 ; Lung cancer ; Lungs ; Polymorphisms ; Transferases ; الرئتان ; السرطان</subject><ispartof>The Egyptian journal of medical human genetics, 2012-10, Vol.13 (3), p.307-312</ispartof><rights>2012</rights><rights>Copyright Egyptian Society of Medical Human Genetics 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3131-bced3db8305c53e5510c6d0c5946dae79e1b054adb9fd74b62aa7b197981a1d73</citedby><cites>FETCH-LOGICAL-c3131-bced3db8305c53e5510c6d0c5946dae79e1b054adb9fd74b62aa7b197981a1d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1110863012000419$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Fatma, B’chir</creatorcontrib><creatorcontrib>Aida, Taieb</creatorcontrib><creatorcontrib>Maurice, J. Arnaud</creatorcontrib><creatorcontrib>Saguem, Saad</creatorcontrib><title>Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample</title><title>The Egyptian journal of medical human genetics</title><description>The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility. Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the bioactivation and detoxification of tobacco carcinogens and may therefore affect lung cancer risk.
In order to assess association between lung cancer and GSTT1, GSTM1 and CYP1A2-2467T/delT, variant allele (CYP1A2*1D) polymorphisms, a case–control study of healthy and smoking lung cancer patients in Tunisian population was conducted. Polymorphisms of GSTs were assayed by multiplex PCR. Genotype polymorphism of CYP1A2*1D was determined by PCR-RFLP assay. Odds Ratio was used for analysing results.
There was no association with any increase of lung cancer risk in GSTT1 null genotype [OR: 0.83 (0.47–1.45)] as well as in GSTM1 null genotype [OR: 0.78 (0.37–1.62)]. However, a significant association between lung cancer and the homozygous mutate variant of the CYP1A2 [(OR=4.7 (1.55–29.78)] was observed.
These results demonstrated that the strong and significant association between CYP1A2*1D and lung cancer appears to be relevant in this Tunisian population, suggesting that CYP1A2 metabolic genetic factor may, in partly, play a role in modulating lung cancer susceptibility.</description><subject>Cancer</subject><subject>CYP1A2</subject><subject>Glutathione</subject><subject>GSTT1</subject><subject>GSTTM1</subject><subject>Lung cancer</subject><subject>Lungs</subject><subject>Polymorphisms</subject><subject>Transferases</subject><subject>الرئتان</subject><subject>السرطان</subject><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMFu1DAQhi0EEkvhCRCSJa4k9cSxszlwqFalrVQEEuHAyXLsSdfBcYKdIFW8PG634sjJh_n-fzwfIW-BlcBAno8ljtPxrqwYVCUTJWPwjOwq1rKiqmt4TnYAwIq95OwleZXSyJgUvKl35M-V31a9Ht0ckH4r1qhDGjDqhPQzUB0s7eADPfz4ChdV7pJNd27Rd3SZ_f00x-Xo0pQeuTAHmibtfWHQe-q3cEeNDgYjjS79pC7QbgsuOZ05PS0eX5MXg_YJ3zy9Z-T7p8vucF3cfrm6OVzcFoYDh6I3aLnt95wJIzgKAcxIy4xoa2k1Ni1Cz0Stbd8Otql7WWnd9NA27R402Iafkfen3iXOvzZMqxrnLYa8UkElJRcNcJ4pfqJMnFOKOKgluknHewVMPVhWo3q0rB4sKyZUtpxT704pzCgO-l8of53VMs8_Ps3zgb8dRpWMw2zFuohmVXZ2_-3_C8Dlj0g</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Fatma, B’chir</creator><creator>Aida, Taieb</creator><creator>Maurice, J. Arnaud</creator><creator>Saguem, Saad</creator><general>Elsevier B.V</general><general>Egyptian Society of Human Genetics</general><general>Springer Nature B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>ADJCN</scope><scope>AGQTG</scope><scope>AHFXO</scope><scope>AHHHR</scope><scope>AHQOB</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>201210</creationdate><title>Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample</title><author>Fatma, B’chir ; Aida, Taieb ; Maurice, J. Arnaud ; Saguem, Saad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3131-bced3db8305c53e5510c6d0c5946dae79e1b054adb9fd74b62aa7b197981a1d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cancer</topic><topic>CYP1A2</topic><topic>Glutathione</topic><topic>GSTT1</topic><topic>GSTTM1</topic><topic>Lung cancer</topic><topic>Lungs</topic><topic>Polymorphisms</topic><topic>Transferases</topic><topic>الرئتان</topic><topic>السرطان</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatma, B’chir</creatorcontrib><creatorcontrib>Aida, Taieb</creatorcontrib><creatorcontrib>Maurice, J. Arnaud</creatorcontrib><creatorcontrib>Saguem, Saad</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>دراسات مغاربية - e-Marefa Maghreb Studies</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>دراسات الشرق الأوسط - e-Marefa Middle Eastern Studies</collection><collection>الشؤون الدولية والعربية - e-Marefa International & Arab Affairs</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>The Egyptian journal of medical human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatma, B’chir</au><au>Aida, Taieb</au><au>Maurice, J. Arnaud</au><au>Saguem, Saad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample</atitle><jtitle>The Egyptian journal of medical human genetics</jtitle><date>2012-10</date><risdate>2012</risdate><volume>13</volume><issue>3</issue><spage>307</spage><epage>312</epage><pages>307-312</pages><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility. Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the bioactivation and detoxification of tobacco carcinogens and may therefore affect lung cancer risk.
In order to assess association between lung cancer and GSTT1, GSTM1 and CYP1A2-2467T/delT, variant allele (CYP1A2*1D) polymorphisms, a case–control study of healthy and smoking lung cancer patients in Tunisian population was conducted. Polymorphisms of GSTs were assayed by multiplex PCR. Genotype polymorphism of CYP1A2*1D was determined by PCR-RFLP assay. Odds Ratio was used for analysing results.
There was no association with any increase of lung cancer risk in GSTT1 null genotype [OR: 0.83 (0.47–1.45)] as well as in GSTM1 null genotype [OR: 0.78 (0.37–1.62)]. However, a significant association between lung cancer and the homozygous mutate variant of the CYP1A2 [(OR=4.7 (1.55–29.78)] was observed.
These results demonstrated that the strong and significant association between CYP1A2*1D and lung cancer appears to be relevant in this Tunisian population, suggesting that CYP1A2 metabolic genetic factor may, in partly, play a role in modulating lung cancer susceptibility.</abstract><cop>Cairo, Egypt</cop><pub>Elsevier B.V</pub><doi>10.1016/j.ejmhg.2012.05.001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1110-8630 |
| ispartof | The Egyptian journal of medical human genetics, 2012-10, Vol.13 (3), p.307-312 |
| issn | 1110-8630 2090-2441 |
| language | eng |
| recordid | cdi_proquest_journals_1266357133 |
| source | African Journals Online (Open Access); DOAJ Directory of Open Access Journals; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cancer CYP1A2 Glutathione GSTT1 GSTTM1 Lung cancer Lungs Polymorphisms Transferases الرئتان السرطان |
| title | Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A36%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutathione%20S-transferase%20M1%20and%20T1,%20CYP1A2-2467T/delT%20polymorphisms%20and%20non%20small-cell%20lung%20cancer%20risk%20in%20Tunisian%20sample&rft.jtitle=The%20Egyptian%20journal%20of%20medical%20human%20genetics&rft.au=Fatma,%20B%E2%80%99chir&rft.date=2012-10&rft.volume=13&rft.issue=3&rft.spage=307&rft.epage=312&rft.pages=307-312&rft.issn=1110-8630&rft.eissn=2090-2441&rft_id=info:doi/10.1016/j.ejmhg.2012.05.001&rft_dat=%3Cproquest_cross%3E2856957431%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1266357133&rft_id=info:pmid/&rft_els_id=S1110863012000419&rfr_iscdi=true |