Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C

In this small, preliminary study of sofosbuvir, a nucleotide inhibitor of HCV polymerase, treatment with sofosbuvir and ribavirin, without peginterferon, was effective in achieving a sustained virologic response in patients with HCV genotype 1, 2, or 3 infection. Recent progress in the treatment of...

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Veröffentlicht in:	The New England journal of medicine 2013-01, Vol.368 (1), p.34-44
Hauptverfasser:	Gane, Edward J, Stedman, Catherine A, Hyland, Robert H, Ding, Xiao, Svarovskaia, Evguenia, Symonds, William T, Hindes, Robert G, Berrey, M. Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Biological and medical sciences Drug therapy Drug Therapy, Combination Female General aspects Genotype Hemoglobins - metabolism Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis Hepatitis C Hepatitis C, Chronic - blood Hepatitis C, Chronic - drug therapy Human viral diseases Humans Infections Infectious diseases Interferon Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Male Medical sciences Middle Aged Pharmacology. Drug treatments Polyethylene Glycols - adverse effects Polyethylene Glycols - therapeutic use Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Ribavirin - adverse effects Ribavirin - therapeutic use RNA, Viral - metabolism Sofosbuvir Uridine Monophosphate - adverse effects Uridine Monophosphate - analogs & derivatives Uridine Monophosphate - therapeutic use Viral diseases Viral hepatitis Viral Load Viral Nonstructural Proteins - antagonists & inhibitors
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