A Fluorescence-Based Assay for p38[alpha] Recruitment Site Binders: Identification of Rooperol as a Novel p38[alpha] Kinase Inhibitor

A Fluorescence-Based Assay for p38[alpha] Recruitment Site Binders: Identification of Rooperol as a Novel p38[alpha] Kinase Inhibitor

A new p38α inhibitor: Using a D-recruitment site (DRS) probe for p38α which exploits covalent interaction with Cys119 and alkyne-azide "click" chemistry to identify small molecules that recognize the p38α DRS, the anti-inflammatory natural product rooperol was identified as a novel p38α in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chembiochem : a European journal of chemical biology 2013-01, Vol.14 (1), p.66
Hauptverfasser: Li, Jing, Kaoud, Tamer S, LeVieux, Jake, Gilbreath, Brad, Moharana, Swapna, Dalby, Kevin N, Kerwin, Sean M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new p38α inhibitor: Using a D-recruitment site (DRS) probe for p38α which exploits covalent interaction with Cys119 and alkyne-azide "click" chemistry to identify small molecules that recognize the p38α DRS, the anti-inflammatory natural product rooperol was identified as a novel p38α inhibitor.
ISSN:1439-4227
1439-7633