Update to CDC’s Sexually Transmitted Diseases Treatment Guidelines, 2010: Oral Cephalosporins No Longer a Recommended Treatment for Gonococcal Infections

Gonorrhea is a reproductive complications in women and can facilitate human immunodeficiency virus (HIV) transmission. Effective treatment is a cornerstone of US gonorrhea control efforts, but treatment of gonorrhea has been complicated by the ability of Neisseria gonorrhoeae to develop anti-microbi...

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2012-11, Vol.308 (18), p.1850-1853
Hauptverfasser: del Rio, Carlos, Hall, Geraldine, Holmes, King, Soge, Olusegun, Hook, Edward W, Kirkcaldy, Robert D, Workowski, Kimberly A, Kidd, Sarah, Weinstock, Hillard S, Papp, John R, Trees, David, Peterman, Thomas A, Bolan, Gail
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container_issue 18
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container_title JAMA : the journal of the American Medical Association
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creator del Rio, Carlos
Hall, Geraldine
Holmes, King
Soge, Olusegun
Hook, Edward W
Kirkcaldy, Robert D
Workowski, Kimberly A
Kidd, Sarah
Weinstock, Hillard S
Papp, John R
Trees, David
Peterman, Thomas A
Bolan, Gail
description Gonorrhea is a reproductive complications in women and can facilitate human immunodeficiency virus (HIV) transmission. Effective treatment is a cornerstone of US gonorrhea control efforts, but treatment of gonorrhea has been complicated by the ability of Neisseria gonorrhoeae to develop anti-microbial resistance. This report, using data from CDC's Gonococcal Isolate Surveillance Project (GISP), describes laboratory evidence of declining cefixime susceptibility among urethral N. gonorrhoeae isolates collected in the United States during 2006-11 and updates CDC's current recommendations for treatment of gonorrhea. CDC no longer recommends cefixime at any dose as a first-line regimen for treatment of gonococcal infections. If cefixime is used as an alternative agent, then the patient should return in 1 week for a test-of-cure at the site of infection.
doi_str_mv 10.1001/2012.jama.11292
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subjects Drug resistance
Drug therapy
Evidence-based medicine
Gonorrhea
Medical treatment
title Update to CDC’s Sexually Transmitted Diseases Treatment Guidelines, 2010: Oral Cephalosporins No Longer a Recommended Treatment for Gonococcal Infections
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