Human Cord Blood-Derived Mast Cells Are Activated by the Nod1 Agonist M-TriDAP to Release Pro-Inflammatory Cytokines and Chemokines
Mast cells are among the first cells of our immune system to encounter exogenous danger. Intracellular receptors such as nucleotide-binding oligomerization domain (Nod) play an important role in responding to invading pathogens. Here, we have investigated the response of human mast cells to the Nod1...
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| Veröffentlicht in: | Journal of innate immunity 2011-01, Vol.3 (2), p.142-149 |
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| creator | Enoksson, Mattias Ejendal, Karin F.K. McAlpine, Sarah Nilsson, Gunnar Lunderius-Andersson, Carolina |
| description | Mast cells are among the first cells of our immune system to encounter exogenous danger. Intracellular receptors such as nucleotide-binding oligomerization domain (Nod) play an important role in responding to invading pathogens. Here, we have investigated the response of human mast cells to the Nod1 ligand M-TriDAP. Human cord blood-derived mast cells (CBMCs) were activated with M-TriDAP alone, or in combination with the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS) and zymosan. Release of pro-inflammatory chemokines and cytokines was measured by ELISA, cytometric bead array and LUMINEX, and degranulation was evaluated by analysis of histamine release. M-TriDAP induced a dose-dependent release of IL-8, MIP-1α, MIP-1β and TNF. In contrast, degranulation could not be observed. When cells were treated with M-TriDAP in combination with the TLR4 agonist LPS, but not with TLR2 agonist zymosan, the secretion of cytokines was augmented. We here present results demonstrating that human CBMCs are stimulated by the Nod1 agonist M-TriDAP alone and in combination with LPS to produce pro-inflammatory cytokines and chemokines. Our results add to the concept that mast cells constitute an important part of our host defense, as they are equipped with several types of important pattern recognition receptors, including TLRs and Nod. |
| doi_str_mv | 10.1159/000321933 |
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Intracellular receptors such as nucleotide-binding oligomerization domain (Nod) play an important role in responding to invading pathogens. Here, we have investigated the response of human mast cells to the Nod1 ligand M-TriDAP. Human cord blood-derived mast cells (CBMCs) were activated with M-TriDAP alone, or in combination with the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS) and zymosan. Release of pro-inflammatory chemokines and cytokines was measured by ELISA, cytometric bead array and LUMINEX, and degranulation was evaluated by analysis of histamine release. M-TriDAP induced a dose-dependent release of IL-8, MIP-1α, MIP-1β and TNF. In contrast, degranulation could not be observed. When cells were treated with M-TriDAP in combination with the TLR4 agonist LPS, but not with TLR2 agonist zymosan, the secretion of cytokines was augmented. We here present results demonstrating that human CBMCs are stimulated by the Nod1 agonist M-TriDAP alone and in combination with LPS to produce pro-inflammatory cytokines and chemokines. Our results add to the concept that mast cells constitute an important part of our host defense, as they are equipped with several types of important pattern recognition receptors, including TLRs and Nod.</description><identifier>ISSN: 1662-811X</identifier><identifier>EISSN: 1662-8128</identifier><identifier>DOI: 10.1159/000321933</identifier><identifier>PMID: 21099203</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Acetylglucosamine ; Biological and medical sciences ; Chemokines - metabolism ; Cytokines - metabolism ; Fetal Blood - cytology ; Fetal Blood - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Genetics of the immune response ; Humans ; Immunobiology ; Inflammation ; Ligands ; Lipopolysaccharides - immunology ; Mast Cells - immunology ; Mast Cells - metabolism ; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) ; Molecular and cellular biology ; Muramic Acids ; Nod1 Signaling Adaptor Protein - agonists ; Nod1 Signaling Adaptor Protein - chemistry ; Nod1 Signaling Adaptor Protein - immunology ; Nod1 Signaling Adaptor Protein - metabolism ; Peptide Fragments - immunology ; Peptidoglycan - immunology ; Research Article ; Substrate Specificity ; Toll-Like Receptors - immunology ; Toll-Like Receptors - metabolism</subject><ispartof>Journal of innate immunity, 2011-01, Vol.3 (2), p.142-149</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-37c4e4cc360ae8742077dcf47fa1b623b16ba06c0dc56e4585ef01d4e53b83093</citedby><cites>FETCH-LOGICAL-c502t-37c4e4cc360ae8742077dcf47fa1b623b16ba06c0dc56e4585ef01d4e53b83093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23836553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21099203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:122014025$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Enoksson, Mattias</creatorcontrib><creatorcontrib>Ejendal, Karin F.K.</creatorcontrib><creatorcontrib>McAlpine, Sarah</creatorcontrib><creatorcontrib>Nilsson, Gunnar</creatorcontrib><creatorcontrib>Lunderius-Andersson, Carolina</creatorcontrib><title>Human Cord Blood-Derived Mast Cells Are Activated by the Nod1 Agonist M-TriDAP to Release Pro-Inflammatory Cytokines and Chemokines</title><title>Journal of innate immunity</title><addtitle>J Innate Immun</addtitle><description>Mast cells are among the first cells of our immune system to encounter exogenous danger. Intracellular receptors such as nucleotide-binding oligomerization domain (Nod) play an important role in responding to invading pathogens. Here, we have investigated the response of human mast cells to the Nod1 ligand M-TriDAP. Human cord blood-derived mast cells (CBMCs) were activated with M-TriDAP alone, or in combination with the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS) and zymosan. Release of pro-inflammatory chemokines and cytokines was measured by ELISA, cytometric bead array and LUMINEX, and degranulation was evaluated by analysis of histamine release. M-TriDAP induced a dose-dependent release of IL-8, MIP-1α, MIP-1β and TNF. In contrast, degranulation could not be observed. When cells were treated with M-TriDAP in combination with the TLR4 agonist LPS, but not with TLR2 agonist zymosan, the secretion of cytokines was augmented. We here present results demonstrating that human CBMCs are stimulated by the Nod1 agonist M-TriDAP alone and in combination with LPS to produce pro-inflammatory cytokines and chemokines. Our results add to the concept that mast cells constitute an important part of our host defense, as they are equipped with several types of important pattern recognition receptors, including TLRs and Nod.</description><subject>Acetylglucosamine</subject><subject>Biological and medical sciences</subject><subject>Chemokines - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Fetal Blood - cytology</subject><subject>Fetal Blood - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>Genetics of the immune response</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Inflammation</subject><subject>Ligands</subject><subject>Lipopolysaccharides - immunology</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - metabolism</subject><subject>Mathematics in biology. Statistical analysis. Models. Metrology. 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Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>Genetics of the immune response</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Inflammation</topic><topic>Ligands</topic><topic>Lipopolysaccharides - immunology</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - metabolism</topic><topic>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</topic><topic>Molecular and cellular biology</topic><topic>Muramic Acids</topic><topic>Nod1 Signaling Adaptor Protein - agonists</topic><topic>Nod1 Signaling Adaptor Protein - chemistry</topic><topic>Nod1 Signaling Adaptor Protein - immunology</topic><topic>Nod1 Signaling Adaptor Protein - metabolism</topic><topic>Peptide Fragments - immunology</topic><topic>Peptidoglycan - immunology</topic><topic>Research Article</topic><topic>Substrate Specificity</topic><topic>Toll-Like Receptors - immunology</topic><topic>Toll-Like Receptors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enoksson, Mattias</creatorcontrib><creatorcontrib>Ejendal, Karin F.K.</creatorcontrib><creatorcontrib>McAlpine, Sarah</creatorcontrib><creatorcontrib>Nilsson, Gunnar</creatorcontrib><creatorcontrib>Lunderius-Andersson, Carolina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of innate immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enoksson, Mattias</au><au>Ejendal, Karin F.K.</au><au>McAlpine, Sarah</au><au>Nilsson, Gunnar</au><au>Lunderius-Andersson, Carolina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Cord Blood-Derived Mast Cells Are Activated by the Nod1 Agonist M-TriDAP to Release Pro-Inflammatory Cytokines and Chemokines</atitle><jtitle>Journal of innate immunity</jtitle><addtitle>J Innate Immun</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>3</volume><issue>2</issue><spage>142</spage><epage>149</epage><pages>142-149</pages><issn>1662-811X</issn><eissn>1662-8128</eissn><abstract>Mast cells are among the first cells of our immune system to encounter exogenous danger. Intracellular receptors such as nucleotide-binding oligomerization domain (Nod) play an important role in responding to invading pathogens. Here, we have investigated the response of human mast cells to the Nod1 ligand M-TriDAP. Human cord blood-derived mast cells (CBMCs) were activated with M-TriDAP alone, or in combination with the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS) and zymosan. Release of pro-inflammatory chemokines and cytokines was measured by ELISA, cytometric bead array and LUMINEX, and degranulation was evaluated by analysis of histamine release. M-TriDAP induced a dose-dependent release of IL-8, MIP-1α, MIP-1β and TNF. In contrast, degranulation could not be observed. When cells were treated with M-TriDAP in combination with the TLR4 agonist LPS, but not with TLR2 agonist zymosan, the secretion of cytokines was augmented. We here present results demonstrating that human CBMCs are stimulated by the Nod1 agonist M-TriDAP alone and in combination with LPS to produce pro-inflammatory cytokines and chemokines. Our results add to the concept that mast cells constitute an important part of our host defense, as they are equipped with several types of important pattern recognition receptors, including TLRs and Nod.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>21099203</pmid><doi>10.1159/000321933</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylglucosamine Biological and medical sciences Chemokines - metabolism Cytokines - metabolism Fetal Blood - cytology Fetal Blood - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Genetics of the immune response Humans Immunobiology Inflammation Ligands Lipopolysaccharides - immunology Mast Cells - immunology Mast Cells - metabolism Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Molecular and cellular biology Muramic Acids Nod1 Signaling Adaptor Protein - agonists Nod1 Signaling Adaptor Protein - chemistry Nod1 Signaling Adaptor Protein - immunology Nod1 Signaling Adaptor Protein - metabolism Peptide Fragments - immunology Peptidoglycan - immunology Research Article Substrate Specificity Toll-Like Receptors - immunology Toll-Like Receptors - metabolism |
| title | Human Cord Blood-Derived Mast Cells Are Activated by the Nod1 Agonist M-TriDAP to Release Pro-Inflammatory Cytokines and Chemokines |
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