Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma

CXCL5 (epithelial neutrophil‐activating peptide‐78) is a member of a proangiogenic subgroup of the CXC‐type chemokine family of small, secreted proteins. Recently, evidence that CXCL5 is involved in carcinogenesis and cancer progression has emerged. To investigate the role of CXCL5 in tumor growth,...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-12, Vol.56 (6), p.2242-2254
Hauptverfasser:	Zhou, Shao-Lai, Dai, Zhi, Zhou, Zheng-Jun, Wang, Xiao-Ying, Yang, Guo-Huan, Wang, Zheng, Huang, Xiao-Wu, Fan, Jia, Zhou, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cancer Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - secondary Cell Proliferation Chemokine CXCL5 - drug effects Chemokine CXCL5 - genetics Chemokine CXCL5 - metabolism Chemotaxis, Leukocyte Female Gastroenterology. Liver. Pancreas. Abdomen Hep G2 Cells Hepatology Humans Kaplan-Meier Estimate Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male MAP Kinase Signaling System Medical sciences Mice Mice, Nude Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Recurrence, Local - metabolism Neutrophils - physiology Phosphatidylinositol 3-Kinases - metabolism Prognosis Proportional Hazards Models Proteins Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Tumors Up-Regulation
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