A simple Bayesian decision-theoretic design for dose-finding trials

A flexible and simple Bayesian decision‐theoretic design for dose‐finding trials is proposed in this paper. In order to reduce the computational burden, we adopt a working model with conjugate priors, which is flexible to fit all monotonic dose‐toxicity curves and produces analytic posterior distrib...

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Veröffentlicht in:	Statistics in medicine 2012-12, Vol.31 (28), p.3719-3730
Hauptverfasser:	Fan, Shenghua Kelly, Lu, Ying, Wang, You-Gan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Bayes Theorem Bayesian adaptive designs Bayesian analysis Clinical Trials as Topic - methods Clinical Trials as Topic - standards Computer Simulation Cytotoxins - administration & dosage Cytotoxins - pharmacokinetics Decision Theory dose-finding trials Dose-Response Relationship, Drug Humans Logistic Models Maximum Tolerated Dose Regression (Psychology) Research Design Simulation Statistics, Nonparametric Toxicity Utility functions
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