Directed Modulation of Protein KinaseC Isozyme Selectivity with Bisubstrate-Based Inhibitors

Kinases present an attractive target for drug development, since they are involved in vital cellular processes and are implicated in a variety of diseases, such as cancer and diabetes. However, obtaining selectivity for a specific kinase over others is difficult since many current kinase inhibitors...

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Veröffentlicht in:	ChemMedChem 2012-12, Vol.7 (12), p.2113
Hauptverfasser:	vanWandelen, Loek T. M, vanAmeijde, Jeroen, Mady, Ahmed S. A, Wammes, Angelique E. M, Bode, Alois, Poot, Alex J, Ruijtenbeek, Rob, Liskamp, Rob M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Kinases
Online-Zugang:	Volltext
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