Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 tesla MRI
Purpose: To characterize the effects of pressure‐driven brain infusions using high field intra‐operative MRI. Understanding these effects is critical for upcoming neurodegeneration and oncology trials using convection‐enhanced delivery (CED) to achieve large drug distributions with minimal off‐targe...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2012-12, Vol.36 (6), p.1339-1346 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Rosenbluth, Kathryn H. Martin, Alastair J. Bringas, John Bankiewicz, Krystof S. |
| description | Purpose:
To characterize the effects of pressure‐driven brain infusions using high field intra‐operative MRI. Understanding these effects is critical for upcoming neurodegeneration and oncology trials using convection‐enhanced delivery (CED) to achieve large drug distributions with minimal off‐target exposure.
Materials and Methods:
High‐resolution T2‐weighted and diffusion‐tensor images were acquired serially on a 7 Tesla MRI scanner during six CED infusions in nonhuman primates. The images were used to evaluate the size, distribution, diffusivity, and temporal dynamics of the infusions.
Results:
The infusion distribution had high contrast in the T2‐weighted images. Diffusion tensor images showed the infusion increased diffusivity, reduced tortuosity, and reduced anisotropy. These results suggested CED caused an increase in the extracellular space.
Conclusion:
High‐field intra‐operative MRI can be used to monitor the distribution of infusate and changes in the geometry of the brain's porous matrix. These techniques could be used to optimize the effectiveness of pressure‐driven drug delivery to the brain. J. Magn. Reson. Imaging 2012; 36:1339–1346. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.23771 |
| format | Article |
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To characterize the effects of pressure‐driven brain infusions using high field intra‐operative MRI. Understanding these effects is critical for upcoming neurodegeneration and oncology trials using convection‐enhanced delivery (CED) to achieve large drug distributions with minimal off‐target exposure.
Materials and Methods:
High‐resolution T2‐weighted and diffusion‐tensor images were acquired serially on a 7 Tesla MRI scanner during six CED infusions in nonhuman primates. The images were used to evaluate the size, distribution, diffusivity, and temporal dynamics of the infusions.
Results:
The infusion distribution had high contrast in the T2‐weighted images. Diffusion tensor images showed the infusion increased diffusivity, reduced tortuosity, and reduced anisotropy. These results suggested CED caused an increase in the extracellular space.
Conclusion:
High‐field intra‐operative MRI can be used to monitor the distribution of infusate and changes in the geometry of the brain's porous matrix. These techniques could be used to optimize the effectiveness of pressure‐driven drug delivery to the brain. J. Magn. Reson. Imaging 2012; 36:1339–1346. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.23771</identifier><identifier>PMID: 22887937</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>7T MRI ; Animals ; Brain - anatomy & histology ; Brain - metabolism ; convection-enhanced drug delivery ; diffusion ; extracellular space ; Infusions, Intraventricular ; Macaca mulatta ; Magnetic resonance imaging ; Magnetic Resonance Imaging, Interventional - methods ; nonhuman primate ; Pressure ; Reproducibility of Results ; Sensitivity and Specificity ; Sodium Chloride - administration & dosage ; Sodium Chloride - pharmacokinetics ; Tissue Distribution</subject><ispartof>Journal of magnetic resonance imaging, 2012-12, Vol.36 (6), p.1339-1346</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4311-95ea7cb8324f293763c6d10cf5a1248142949bc875a66727058952f157d48abc3</citedby><cites>FETCH-LOGICAL-c4311-95ea7cb8324f293763c6d10cf5a1248142949bc875a66727058952f157d48abc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.23771$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.23771$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22887937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenbluth, Kathryn H.</creatorcontrib><creatorcontrib>Martin, Alastair J.</creatorcontrib><creatorcontrib>Bringas, John</creatorcontrib><creatorcontrib>Bankiewicz, Krystof S.</creatorcontrib><title>Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 tesla MRI</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To characterize the effects of pressure‐driven brain infusions using high field intra‐operative MRI. Understanding these effects is critical for upcoming neurodegeneration and oncology trials using convection‐enhanced delivery (CED) to achieve large drug distributions with minimal off‐target exposure.
Materials and Methods:
High‐resolution T2‐weighted and diffusion‐tensor images were acquired serially on a 7 Tesla MRI scanner during six CED infusions in nonhuman primates. The images were used to evaluate the size, distribution, diffusivity, and temporal dynamics of the infusions.
Results:
The infusion distribution had high contrast in the T2‐weighted images. Diffusion tensor images showed the infusion increased diffusivity, reduced tortuosity, and reduced anisotropy. These results suggested CED caused an increase in the extracellular space.
Conclusion:
High‐field intra‐operative MRI can be used to monitor the distribution of infusate and changes in the geometry of the brain's porous matrix. These techniques could be used to optimize the effectiveness of pressure‐driven drug delivery to the brain. J. Magn. Reson. Imaging 2012; 36:1339–1346. © 2012 Wiley Periodicals, Inc.</description><subject>7T MRI</subject><subject>Animals</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>convection-enhanced drug delivery</subject><subject>diffusion</subject><subject>extracellular space</subject><subject>Infusions, Intraventricular</subject><subject>Macaca mulatta</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging, Interventional - methods</subject><subject>nonhuman primate</subject><subject>Pressure</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Sodium Chloride - pharmacokinetics</subject><subject>Tissue Distribution</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1PwjAUhhujEURv_AGmiXcmw36sa3dpCCIGNCrqZdNtXRyODtsN5d9bmHDpVU96nvO05wXgHKM-Rohczxe26BPKOT4AXcwICQgT0aGvEaMBFoh3wIlzc4RQHIfsGHQIEYLHlHeBGq5U2ai6qAyscri02rnG6iCzxUobmFhVGFiYvHGecL6CpjIfzUIZzxYLVWsHk7W_r60KqqW2XrXSkEPfKBWcPo9PwVGuSqfP_s4eeL0dzgZ3weRxNB7cTII0pBgHMdOKp4mgJMyJ_1pE0yjDKM2ZwiQUOCRxGCep4ExFESccMREzkmPGs1CoJKU9cNl6l7b6arSr5bxqrPFPSow54lHIY-Kpq5ZKbeWc1bncrmHXEiO5SVNu0pTbND188adskoXO9uguPg_gFvguSr3-RyXvfRI7adDOFK7WP_sZZT9lxCln8v1hJMXsbfL0QqdyQH8BfgaOLg</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Rosenbluth, Kathryn H.</creator><creator>Martin, Alastair J.</creator><creator>Bringas, John</creator><creator>Bankiewicz, Krystof S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>201212</creationdate><title>Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 tesla MRI</title><author>Rosenbluth, Kathryn H. ; Martin, Alastair J. ; Bringas, John ; Bankiewicz, Krystof S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4311-95ea7cb8324f293763c6d10cf5a1248142949bc875a66727058952f157d48abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>7T MRI</topic><topic>Animals</topic><topic>Brain - anatomy & histology</topic><topic>Brain - metabolism</topic><topic>convection-enhanced drug delivery</topic><topic>diffusion</topic><topic>extracellular space</topic><topic>Infusions, Intraventricular</topic><topic>Macaca mulatta</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging, Interventional - methods</topic><topic>nonhuman primate</topic><topic>Pressure</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Sodium Chloride - pharmacokinetics</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenbluth, Kathryn H.</creatorcontrib><creatorcontrib>Martin, Alastair J.</creatorcontrib><creatorcontrib>Bringas, John</creatorcontrib><creatorcontrib>Bankiewicz, Krystof S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenbluth, Kathryn H.</au><au>Martin, Alastair J.</au><au>Bringas, John</au><au>Bankiewicz, Krystof S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 tesla MRI</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2012-12</date><risdate>2012</risdate><volume>36</volume><issue>6</issue><spage>1339</spage><epage>1346</epage><pages>1339-1346</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To characterize the effects of pressure‐driven brain infusions using high field intra‐operative MRI. Understanding these effects is critical for upcoming neurodegeneration and oncology trials using convection‐enhanced delivery (CED) to achieve large drug distributions with minimal off‐target exposure.
Materials and Methods:
High‐resolution T2‐weighted and diffusion‐tensor images were acquired serially on a 7 Tesla MRI scanner during six CED infusions in nonhuman primates. The images were used to evaluate the size, distribution, diffusivity, and temporal dynamics of the infusions.
Results:
The infusion distribution had high contrast in the T2‐weighted images. Diffusion tensor images showed the infusion increased diffusivity, reduced tortuosity, and reduced anisotropy. These results suggested CED caused an increase in the extracellular space.
Conclusion:
High‐field intra‐operative MRI can be used to monitor the distribution of infusate and changes in the geometry of the brain's porous matrix. These techniques could be used to optimize the effectiveness of pressure‐driven drug delivery to the brain. J. Magn. Reson. Imaging 2012; 36:1339–1346. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22887937</pmid><doi>10.1002/jmri.23771</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 7T MRI Animals Brain - anatomy & histology Brain - metabolism convection-enhanced drug delivery diffusion extracellular space Infusions, Intraventricular Macaca mulatta Magnetic resonance imaging Magnetic Resonance Imaging, Interventional - methods nonhuman primate Pressure Reproducibility of Results Sensitivity and Specificity Sodium Chloride - administration & dosage Sodium Chloride - pharmacokinetics Tissue Distribution |
| title | Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 tesla MRI |
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