Organocatalytic Asymmetric Double Michael Reaction of Benzofuranone with Dienones to Construct Spirocyclic Benzofuranones

The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% yield and 91% ee.

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Bibliographische Detailangaben
Veröffentlicht in:	Chinese journal of chemistry 2012-11, Vol.30 (11), p.2703-2706
1. Verfasser:	罗西娅汪亮完彭林摆建飞贾利娜田芳徐小英王立新
Format:	Artikel
Sprache:	eng
Schlagworte:	benzofuranone double Michael reaction Michael加成反应 organocatalysis spirocyclic compounds 不对称伯胺光学活性对映选择性有机催化苯并呋喃酮螺环
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Beschreibung
Zusammenfassung:	The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% yield and 91% ee.
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201200676