Fractionated doses of gemtuzumab ozogamicin combined with 3 + 7 induction chemotherapy as salvage treatment for young patients with acute myeloid leukemia in first relapse

Current salvage therapies for relapsed acute myeloid leukemia (AML) are unsatisfactory. We retrospectively evaluated the efficacy and toxicity of fractionated doses of gemtuzumab ozogamicin (GO) combined with a standard 3 + 7 induction regimen in young patients with AML in first relapse. Salvage reg...

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Veröffentlicht in:	Annals of hematology 2012-12, Vol.91 (12), p.1871-1877
Hauptverfasser:	Malfuson, J. V., Konopacki, J., Thepenier, C., Eddou, H., Foissaud, V., de Revel, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aminoglycosides - administration & dosage Aminoglycosides - adverse effects Aminoglycosides - therapeutic use Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Combined Modality Therapy Cytarabine - administration & dosage Cytarabine - adverse effects Cytarabine - therapeutic use Daunorubicin - administration & dosage Daunorubicin - adverse effects Daunorubicin - therapeutic use Drug Administration Schedule Female Follow-Up Studies Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hepatic Veno-Occlusive Disease - chemically induced Hepatic Veno-Occlusive Disease - etiology Hepatic Veno-Occlusive Disease - physiopathology Hepatic Veno-Occlusive Disease - prevention & control Humans Idarubicin - administration & dosage Idarubicin - adverse effects Idarubicin - therapeutic use Induction Chemotherapy - adverse effects Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - therapy Male Medicine Medicine & Public Health Middle Aged Oncology Original Article Recurrence Retrospective Studies Salvage Therapy - adverse effects Severity of Illness Index Survival Analysis
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