Sequential expression of IGF-IB followed by active TGF-[Beta]1 induces synergistic pulmonary fibroproliferation in vivo

Pulmonary fibrosis, the end stage of a variety of fibroproliferative lung diseases, is usually induced after repetitive or chronic lung injury or inflammation. The mechanisms of fibroproliferation are poorly understood. Insulin-like growth factor-I (IGF-I) is significantly elevated in patients with...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2012-11, Vol.303 (9), p.L788
Hauptverfasser:	Andonegui, Graciela, Ni, Ai, Léger, Caroline, Kelly, Margaret M, Wong, Josée F, Jalloul, Ali, Winston, Brent W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines Gene expression Insulin-like growth factors Lymphocytes Respiratory distress syndrome Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!