The Inhibitory Effects of Trastuzumab on Corneal Neovascularization

Purpose To investigate the effect of systemic administration of trastuzumab in the prevention of experimentally induced corneal neovascularization in a rat model. Design An experimental animal study. Methods Sixteen male Wistar-Albino rats weighing 250 g to 300 g were used in the study. Silver nitra...

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Veröffentlicht in:	American journal of ophthalmology 2009-04, Vol.147 (4), p.703-708.e2
Hauptverfasser:	Güler, Mete, Yilmaz, Turgut, Özercan, İbrahim, Elkiran, Tamer
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - administration & dosage Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Corneal Neovascularization - chemically induced Corneal Neovascularization - metabolism Corneal Neovascularization - pathology Corneal Neovascularization - prevention & control Corneal Stroma - metabolism Corneal Stroma - pathology Disease Models, Animal Drug dosages Endothelium, Corneal - metabolism Endothelium, Corneal - pathology Epidermal growth factor Epithelium, Corneal - metabolism Epithelium, Corneal - pathology Immunoenzyme Techniques Injections, Intraperitoneal Male Medicine Nitrates Ophthalmology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Rats Rats, Wistar Receptor, ErbB-2 - metabolism Rodents Silver Nitrate Trastuzumab Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Wound healing
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