The Generation R Study: design and cohort update 2012
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood...
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| Veröffentlicht in: | European journal of epidemiology 2012-09, Vol.27 (9), p.739-756 |
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| container_title | European journal of epidemiology |
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| creator | Jaddoe, Vincent W. V. van Duijn, Cornelia M. Franco, Oscar H. van der Heijden, Albert J. van IIzendoorn, Marinus H. de Jongste, Johan C. van der Lugt, Aad Mackenbach, Johan P. Moll, Henriëtte A. Raat, Hein Rivadeneira, Fernando Steegers, Eric A. P. Tiemeier, Henning Uitterlinden, Andre G. Verhulst, Frank C. Hofman, Albert |
| description | The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children. |
| doi_str_mv | 10.1007/s10654-012-9735-1 |
| format | Article |
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V. ; van Duijn, Cornelia M. ; Franco, Oscar H. ; van der Heijden, Albert J. ; van IIzendoorn, Marinus H. ; de Jongste, Johan C. ; van der Lugt, Aad ; Mackenbach, Johan P. ; Moll, Henriëtte A. ; Raat, Hein ; Rivadeneira, Fernando ; Steegers, Eric A. P. ; Tiemeier, Henning ; Uitterlinden, Andre G. ; Verhulst, Frank C. ; Hofman, Albert</creator><creatorcontrib>Jaddoe, Vincent W. V. ; van Duijn, Cornelia M. ; Franco, Oscar H. ; van der Heijden, Albert J. ; van IIzendoorn, Marinus H. ; de Jongste, Johan C. ; van der Lugt, Aad ; Mackenbach, Johan P. ; Moll, Henriëtte A. ; Raat, Hein ; Rivadeneira, Fernando ; Steegers, Eric A. P. ; Tiemeier, Henning ; Uitterlinden, Andre G. ; Verhulst, Frank C. ; Hofman, Albert</creatorcontrib><description>The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/s10654-012-9735-1</identifier><identifier>PMID: 23086283</identifier><identifier>CODEN: EJEPE8</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Allergies ; Biological and medical sciences ; Biological samples ; Cardiology ; Child ; Child Behavior - physiology ; Child care ; Child development ; Child Development - physiology ; Childhood ; Children ; Cognition ; Cohort Studies ; Data collection ; Data Collection - methods ; Development strategies ; Environment ; Epidemiologic Research Design ; Epidemiology ; Family Characteristics ; Female ; Fetal Development - genetics ; Fetal Development - physiology ; General aspects ; Genome-Wide Association Study ; Growth Disorders - epidemiology ; Growth Disorders - etiology ; Growth Disorders - genetics ; Health ; Health care ; Humans ; Infant ; Infants ; Infectious Diseases ; Male ; Maternal Health Services ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous ; Mortality ; Mothers ; Netherlands - epidemiology ; Oncology ; Physical Examination - methods ; Pregnancy ; Prenatal development ; Public Health ; Public health. 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Hygiene-occupational medicine ; Questionnaires ; Research Design ; School age children ; STUDY UPDATE ; Surveys and Questionnaires ; Ultrasonography ; Young adults</subject><ispartof>European journal of epidemiology, 2012-09, Vol.27 (9), p.739-756</ispartof><rights>Springer Science+Business Media Dordrecht 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-e93bcbaf482a4494f3f72e3c627b731f2d3be01e68c16f201af2c360bca877103</citedby><cites>FETCH-LOGICAL-c467t-e93bcbaf482a4494f3f72e3c627b731f2d3be01e68c16f201af2c360bca877103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23272550$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23272550$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,41488,42557,51319,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26555125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23086283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaddoe, Vincent W. V.</creatorcontrib><creatorcontrib>van Duijn, Cornelia M.</creatorcontrib><creatorcontrib>Franco, Oscar H.</creatorcontrib><creatorcontrib>van der Heijden, Albert J.</creatorcontrib><creatorcontrib>van IIzendoorn, Marinus H.</creatorcontrib><creatorcontrib>de Jongste, Johan C.</creatorcontrib><creatorcontrib>van der Lugt, Aad</creatorcontrib><creatorcontrib>Mackenbach, Johan P.</creatorcontrib><creatorcontrib>Moll, Henriëtte A.</creatorcontrib><creatorcontrib>Raat, Hein</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Steegers, Eric A. P.</creatorcontrib><creatorcontrib>Tiemeier, Henning</creatorcontrib><creatorcontrib>Uitterlinden, Andre G.</creatorcontrib><creatorcontrib>Verhulst, Frank C.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><title>The Generation R Study: design and cohort update 2012</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><addtitle>Eur J Epidemiol</addtitle><description>The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.</description><subject>Adult</subject><subject>Allergies</subject><subject>Biological and medical sciences</subject><subject>Biological samples</subject><subject>Cardiology</subject><subject>Child</subject><subject>Child Behavior - physiology</subject><subject>Child care</subject><subject>Child development</subject><subject>Child Development - physiology</subject><subject>Childhood</subject><subject>Children</subject><subject>Cognition</subject><subject>Cohort Studies</subject><subject>Data collection</subject><subject>Data Collection - methods</subject><subject>Development strategies</subject><subject>Environment</subject><subject>Epidemiologic Research Design</subject><subject>Epidemiology</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Fetal Development - genetics</subject><subject>Fetal Development - physiology</subject><subject>General aspects</subject><subject>Genome-Wide Association Study</subject><subject>Growth Disorders - epidemiology</subject><subject>Growth Disorders - etiology</subject><subject>Growth Disorders - genetics</subject><subject>Health</subject><subject>Health care</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Maternal Health Services</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Mothers</subject><subject>Netherlands - epidemiology</subject><subject>Oncology</subject><subject>Physical Examination - methods</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Public Health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Questionnaires</subject><subject>Research Design</subject><subject>School age children</subject><subject>STUDY UPDATE</subject><subject>Surveys and Questionnaires</subject><subject>Ultrasonography</subject><subject>Young adults</subject><issn>0393-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kD1PwzAURS0EouXjBzCAIiHGwPOzHSdsqIKCVAkJymw5jt2mapNiJ0P_PSkp0InJg8-95-kSckHhlgLIu0AhETwGinEmmYjpARlSIVksMeWHZAgsYzFmGQzISQgLAEghE8dkgAzSBFM2JGI6t9HYVtbrpqyr6C16b9picx8VNpSzKtJVEZl6XvsmateFbmyEne6MHDm9DPZ8956Sj6fH6eg5nryOX0YPk9jwRDaxzVhucu14iprzjDvmJFpmEpS5ZNRhwXIL1CapoYnrirVDwxLIjU6lpMBOyXXfu_b1Z2tDoxZ166tOqShFgcg5io6iPWV8HYK3Tq19udJ-oyio7VCqH0p1l6vtUIp2matdc5uvbPGb-FmmA252gA5GL53XlSnDH5cIIei3HHsudF_VzPq9E_-xX_ahRWhqvydHiUIA-wIDfIZo</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Jaddoe, Vincent W. 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V. ; van Duijn, Cornelia M. ; Franco, Oscar H. ; van der Heijden, Albert J. ; van IIzendoorn, Marinus H. ; de Jongste, Johan C. ; van der Lugt, Aad ; Mackenbach, Johan P. ; Moll, Henriëtte A. ; Raat, Hein ; Rivadeneira, Fernando ; Steegers, Eric A. 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V.</au><au>van Duijn, Cornelia M.</au><au>Franco, Oscar H.</au><au>van der Heijden, Albert J.</au><au>van IIzendoorn, Marinus H.</au><au>de Jongste, Johan C.</au><au>van der Lugt, Aad</au><au>Mackenbach, Johan P.</au><au>Moll, Henriëtte A.</au><au>Raat, Hein</au><au>Rivadeneira, Fernando</au><au>Steegers, Eric A. P.</au><au>Tiemeier, Henning</au><au>Uitterlinden, Andre G.</au><au>Verhulst, Frank C.</au><au>Hofman, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Generation R Study: design and cohort update 2012</atitle><jtitle>European journal of epidemiology</jtitle><stitle>Eur J Epidemiol</stitle><addtitle>Eur J Epidemiol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>27</volume><issue>9</issue><spage>739</spage><epage>756</epage><pages>739-756</pages><issn>0393-2990</issn><eissn>1573-7284</eissn><coden>EJEPE8</coden><abstract>The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. 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| ispartof | European journal of epidemiology, 2012-09, Vol.27 (9), p.739-756 |
| issn | 0393-2990 1573-7284 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals; JSTOR Archive Collection A-Z Listing |
| subjects | Adult Allergies Biological and medical sciences Biological samples Cardiology Child Child Behavior - physiology Child care Child development Child Development - physiology Childhood Children Cognition Cohort Studies Data collection Data Collection - methods Development strategies Environment Epidemiologic Research Design Epidemiology Family Characteristics Female Fetal Development - genetics Fetal Development - physiology General aspects Genome-Wide Association Study Growth Disorders - epidemiology Growth Disorders - etiology Growth Disorders - genetics Health Health care Humans Infant Infants Infectious Diseases Male Maternal Health Services Medical sciences Medicine Medicine & Public Health Miscellaneous Mortality Mothers Netherlands - epidemiology Oncology Physical Examination - methods Pregnancy Prenatal development Public Health Public health. Hygiene Public health. Hygiene-occupational medicine Questionnaires Research Design School age children STUDY UPDATE Surveys and Questionnaires Ultrasonography Young adults |
| title | The Generation R Study: design and cohort update 2012 |
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