[beta]-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

Levels of the pro-tumorigenic prostaglandin PGE(2) are increased in colorectal cancer, previously attributed to increased synthesis through COX-2 upregulation and, more recently, to decreased catabolism. The functionally linked genes 15-prostaglandin dehydrogenase (15-PGDH) and the prostaglandin tra...

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Veröffentlicht in:	British journal of cancer 2012-10, Vol.107 (9), p.1514
Hauptverfasser:	Smartt, H J M, Greenhough, A, Ordóñez-morán, P, Al-kharusi, M, Collard, T J, Mariadason, J M, Huelsken, J, Williams, A C, Paraskeva, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Aspirin Cancer research Colorectal cancer Dehydrogenases Medical research Tumors
Online-Zugang:	Volltext
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