Prostatic Intraepithelial Neoplasia and Apoptosis in Benign Prostatic Hyperplasia Before and After the Chernobyl Accident in Ukraine
The prevalence of prostatic intraepithelial neoplasia (PIN) in men who underwent surgery for benign prostatic hyperplasia (BPH) before and after the Chernobyl nuclear accident was studied. BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and...
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| Veröffentlicht in: | Pathology oncology research 1999-03, Vol.5 (1), p.28-31, Article 28 |
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| creator | Vosianov, Alexander F Romanenko, Alina M Zabarko, Larisa B Szende, Béla Wang, Ching Y Landas, Steven Haas, Gabriel P |
| description | The prevalence of prostatic intraepithelial neoplasia (PIN) in men who underwent surgery for benign prostatic hyperplasia (BPH) before and after the Chernobyl nuclear accident was studied. BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and 47 patients from the low contamined Kiev City (Group II) and 76 from high contaminated area (Group III) operated between 1996 and 1998. Their BPH samples were examined histologically and immunohistochemically. The incidences of prostatic intraepithelial neoplasia (PIN) and high grade PIN (HGPIN) were 15.5 and 11.1% in Group I, 29.8 and 14.9% in Group II, and 35.5 and 19.7% in Group III. The difference between the incidences of PIN in Group I and III is signficant (p |
| doi_str_mv | 10.1053/paor.1999.0028 |
| format | Article |
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BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and 47 patients from the low contamined Kiev City (Group II) and 76 from high contaminated area (Group III) operated between 1996 and 1998. Their BPH samples were examined histologically and immunohistochemically. The incidences of prostatic intraepithelial neoplasia (PIN) and high grade PIN (HGPIN) were 15.5 and 11.1% in Group I, 29.8 and 14.9% in Group II, and 35.5 and 19.7% in Group III. The difference between the incidences of PIN in Group I and III is signficant (p<0.02). There was increased apoptosis in areas of PIN in Group II and III as compared to Group I (p<0.001). Since apoptosis has been shown to be associated with ionizing radiation and it is now found to be associated with PIN in patients diagnosed after the Chernobyl nuclear accident, this suggests that lon-term low dose internal ionizing radiation potentially may cause prostate cancer.Copyright 1999 W.B. Saunders Company Ltd on behalf of the Arányi Lajos Foundation</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1053/paor.1999.0028</identifier><identifier>PMID: 10079374</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Apoptosis ; Biological and medical sciences ; Carcinoma in Situ - epidemiology ; Carcinoma in Situ - etiology ; Carcinoma in Situ - pathology ; Comorbidity ; Environmental Pollution ; Humans ; Incidence ; Male ; Medical sciences ; Men ; Neoplasms, Radiation-Induced - epidemiology ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Radiation-Induced - pathology ; Nephrology. Urinary tract diseases ; Nuclear accidents & safety ; Oncology ; Pathology ; Power Plants ; Precancerous Conditions - epidemiology ; Precancerous Conditions - etiology ; Precancerous Conditions - pathology ; Prevalence ; Prostate cancer ; Prostatectomy ; Prostatic Hyperplasia - epidemiology ; Prostatic Hyperplasia - etiology ; Prostatic Hyperplasia - pathology ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - etiology ; Prostatic Neoplasms - pathology ; Radioactive Hazard Release ; Tumors of the urinary system ; Ukraine - epidemiology ; Urinary tract. Prostate gland</subject><ispartof>Pathology oncology research, 1999-03, Vol.5 (1), p.28-31, Article 28</ispartof><rights>1999 Arányi Lajos Foundation and W.B. 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BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and 47 patients from the low contamined Kiev City (Group II) and 76 from high contaminated area (Group III) operated between 1996 and 1998. Their BPH samples were examined histologically and immunohistochemically. The incidences of prostatic intraepithelial neoplasia (PIN) and high grade PIN (HGPIN) were 15.5 and 11.1% in Group I, 29.8 and 14.9% in Group II, and 35.5 and 19.7% in Group III. The difference between the incidences of PIN in Group I and III is signficant (p<0.02). There was increased apoptosis in areas of PIN in Group II and III as compared to Group I (p<0.001). Since apoptosis has been shown to be associated with ionizing radiation and it is now found to be associated with PIN in patients diagnosed after the Chernobyl nuclear accident, this suggests that lon-term low dose internal ionizing radiation potentially may cause prostate cancer.Copyright 1999 W.B. Saunders Company Ltd on behalf of the Arányi Lajos Foundation</description><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma in Situ - epidemiology</subject><subject>Carcinoma in Situ - etiology</subject><subject>Carcinoma in Situ - pathology</subject><subject>Comorbidity</subject><subject>Environmental Pollution</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Neoplasms, Radiation-Induced - epidemiology</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Nephrology. 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BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and 47 patients from the low contamined Kiev City (Group II) and 76 from high contaminated area (Group III) operated between 1996 and 1998. Their BPH samples were examined histologically and immunohistochemically. The incidences of prostatic intraepithelial neoplasia (PIN) and high grade PIN (HGPIN) were 15.5 and 11.1% in Group I, 29.8 and 14.9% in Group II, and 35.5 and 19.7% in Group III. The difference between the incidences of PIN in Group I and III is signficant (p<0.02). There was increased apoptosis in areas of PIN in Group II and III as compared to Group I (p<0.001). Since apoptosis has been shown to be associated with ionizing radiation and it is now found to be associated with PIN in patients diagnosed after the Chernobyl nuclear accident, this suggests that lon-term low dose internal ionizing radiation potentially may cause prostate cancer.Copyright 1999 W.B. Saunders Company Ltd on behalf of the Arányi Lajos Foundation</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>10079374</pmid><doi>10.1053/paor.1999.0028</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pathology oncology research, 1999-03, Vol.5 (1), p.28-31, Article 28 |
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| subjects | Apoptosis Biological and medical sciences Carcinoma in Situ - epidemiology Carcinoma in Situ - etiology Carcinoma in Situ - pathology Comorbidity Environmental Pollution Humans Incidence Male Medical sciences Men Neoplasms, Radiation-Induced - epidemiology Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Nephrology. Urinary tract diseases Nuclear accidents & safety Oncology Pathology Power Plants Precancerous Conditions - epidemiology Precancerous Conditions - etiology Precancerous Conditions - pathology Prevalence Prostate cancer Prostatectomy Prostatic Hyperplasia - epidemiology Prostatic Hyperplasia - etiology Prostatic Hyperplasia - pathology Prostatic Neoplasms - epidemiology Prostatic Neoplasms - etiology Prostatic Neoplasms - pathology Radioactive Hazard Release Tumors of the urinary system Ukraine - epidemiology Urinary tract. Prostate gland |
| title | Prostatic Intraepithelial Neoplasia and Apoptosis in Benign Prostatic Hyperplasia Before and After the Chernobyl Accident in Ukraine |
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