Comparison of Osteopontin, [beta]-catenin and hnRNP B1 Expression in Lung Carcinomas

Comparison of Osteopontin, [beta]-catenin and hnRNP B1 Expression in Lung Carcinomas

This study was performed to compare osteopontin (OPN), β-catenin and heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) immunreactivities in small cell lung carcinomas (SCLC) and non-small cell lung carcinomas (NSCLC). Correlation of these three antibodies with grade and clinicopathologic stage o...

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Veröffentlicht in:Pathology oncology research 2010-03, Vol.16 (1), p.55
Hauptverfasser: Guldur, Muhammet Emin, Kibar, Yasemin, Deniz, Hale, Bakir, Kemal
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Oncology
Pathology
Skin cancer
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Kibar, Yasemin
Deniz, Hale
Bakir, Kemal
description This study was performed to compare osteopontin (OPN), β-catenin and heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) immunreactivities in small cell lung carcinomas (SCLC) and non-small cell lung carcinomas (NSCLC). Correlation of these three antibodies with grade and clinicopathologic stage of the tumor in NSCLC was also investigated. Twenty-nine SCLC, 6 large cell carcinoma, 36 adenocarcinoma and 30 squamous cell carcinoma (SCC), totally 101 cases, were included in this study. OPN, β-catenin and hnRNP B1 expressions were immunohistochemically evaluated. OPN positivity was 6.9% in SCLC and 67% in NSCLC. When NSCLC types were individually considered, OPN positivity was 66.7% in large cell carcinoma, 80% in SCC and 55.6% in adenocarcinomas. β-catenin positivity was observed in 48.6% of NSCLC and none of SCLC cases. These results were statistically significant (p
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title Comparison of Osteopontin, [beta]-catenin and hnRNP B1 Expression in Lung Carcinomas
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