IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women
To find out which of the following parameters—serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for osteopenia/osteoporosis in women diagnosed...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2008-03, Vol.26 (2), p.159-164 |
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| creator | Liu, Jian-min Zhao, Hong-yan Ning, Guang Chen, Ying Zhang, Lian-zhen Sun, Li-hao Zhao, Yong-ju Xu, Man-yin Chen, Jia-lun |
| description | To find out which of the following parameters—serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for osteopenia/osteoporosis in women diagnosed by dual-energy X-ray absorptiometry (DXA), 282 premenopausal and 222 postmenopausal women aged 20–75 years were investigated by the measurement of bone mineral densities (BMDs) at lumbar spine (LS) and femoral neck (FN) by DXA, together with serum concentrations of IGF-1, OPG, leptin, OC, and urinary NTx. The characteristics of the earliest marker(s) were tested with the receiver operating characteristic (ROC) analysis. The area under the curve (AUC), sensitivity, and specificity parameters were determined. It was revealed that serum levels of IGF-1 and leptin changed the earliest, with both markers significantly decreasing (
P
< 0.0001) or increasing (
P
= 0.020), respectively, at age 30. However, in ROC analysis, IGF-1 was the only early parameter that had the capacity to differentiate the low bone mass/osteoporosis women from the normal ones (
P
< 0.0001). If the serum level of IGF-1 at 1.5 SD below its peak was adopted as a cutoff point, it could identify women with low bone mass/osteoporosis with a sensitivity of 73% and specificity of 67%. In the premenopausal women subgroup analysis, the low bone mass women (30/282, 10.6%) were older (38.2 ± 1.7 vs. 34.5 ± 0.5 years;
P
= 0.026), with lower serum levels of IGF-1 (215.1 ± 22.4 vs. 278.8 ± 9.4 ng/ml;
P
= 0.02) and less lean mass (33.1 ± 0.6 vs. 34.8 ± 0.2 kg;
P
= 0.010) than the normal ones. After controlling for age, the serum level of IGF-1 had a weak, but still significant, positive correlation with lean mass (
r
= 0.17,
P
< 0.001). In conclusion, measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis. |
| doi_str_mv | 10.1007/s00774-007-0799-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1113443751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2793466971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-c0cdeaa5bc069d421fd90f469627a47a1c00f510d83a77f0eefa22bebf8756353</originalsourceid><addsrcrecordid>eNp1kMFOwzAMhiMEYmPwAFxQJMQxYLdJ0xzRxMakSVzgXKVtgja6piSrpu3pybQJduHixM7n3_FPyC3CIwLIpxCD5CxGBlIptjsjQ-SpYCIDfk6GoJCzXEo1IFchLAFQComXZIB5CqhkMiT1bDphSHWguqVG-2ZLV9p_GU-t87RxG1q61sRaCDQWXFgb1znvwiLQRUs7b1amdZ3ug26iRE27iJyUNi4m1-TC6iaYm-M5Ih-Tl_fxK5u_TWfj5zmrBKo1q6CqjdairCBTNU_Q1gosz1SWSM2lxgrACoQ6T7WUFoyxOklKU9pciiwV6YjcH3Q77757E9bF0vW-jSMLREw5T6XASOGBquIawRtbdH4Rl94WCMXe1-Lga7G_7n0tdrHn7qjclytT_3UcjYzAwxHQodKN9bqtFuGXSwDyTHIZueTAhfjUfhp_8sV_p_8AENORIA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1113443751</pqid></control><display><type>article</type><title>IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Liu, Jian-min ; Zhao, Hong-yan ; Ning, Guang ; Chen, Ying ; Zhang, Lian-zhen ; Sun, Li-hao ; Zhao, Yong-ju ; Xu, Man-yin ; Chen, Jia-lun</creator><creatorcontrib>Liu, Jian-min ; Zhao, Hong-yan ; Ning, Guang ; Chen, Ying ; Zhang, Lian-zhen ; Sun, Li-hao ; Zhao, Yong-ju ; Xu, Man-yin ; Chen, Jia-lun</creatorcontrib><description>To find out which of the following parameters—serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for osteopenia/osteoporosis in women diagnosed by dual-energy X-ray absorptiometry (DXA), 282 premenopausal and 222 postmenopausal women aged 20–75 years were investigated by the measurement of bone mineral densities (BMDs) at lumbar spine (LS) and femoral neck (FN) by DXA, together with serum concentrations of IGF-1, OPG, leptin, OC, and urinary NTx. The characteristics of the earliest marker(s) were tested with the receiver operating characteristic (ROC) analysis. The area under the curve (AUC), sensitivity, and specificity parameters were determined. It was revealed that serum levels of IGF-1 and leptin changed the earliest, with both markers significantly decreasing (
P
< 0.0001) or increasing (
P
= 0.020), respectively, at age 30. However, in ROC analysis, IGF-1 was the only early parameter that had the capacity to differentiate the low bone mass/osteoporosis women from the normal ones (
P
< 0.0001). If the serum level of IGF-1 at 1.5 SD below its peak was adopted as a cutoff point, it could identify women with low bone mass/osteoporosis with a sensitivity of 73% and specificity of 67%. In the premenopausal women subgroup analysis, the low bone mass women (30/282, 10.6%) were older (38.2 ± 1.7 vs. 34.5 ± 0.5 years;
P
= 0.026), with lower serum levels of IGF-1 (215.1 ± 22.4 vs. 278.8 ± 9.4 ng/ml;
P
= 0.02) and less lean mass (33.1 ± 0.6 vs. 34.8 ± 0.2 kg;
P
= 0.010) than the normal ones. After controlling for age, the serum level of IGF-1 had a weak, but still significant, positive correlation with lean mass (
r
= 0.17,
P
< 0.001). In conclusion, measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-007-0799-z</identifier><identifier>PMID: 18301972</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Adult ; Age Distribution ; Aged ; Aging ; Area Under Curve ; Biological and medical sciences ; Biomarkers - blood ; Bone and Bones - physiopathology ; Bone Density ; Bones ; Cytokines - blood ; Diagnosis, Differential ; Diseases of the osteoarticular system ; Female ; Femur Neck - physiopathology ; Humans ; Insulin-Like Growth Factor I - metabolism ; Insulin-like growth factors ; Leptin - blood ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Organ Size ; Original Article ; Orthopedics ; Osteoporosis ; Osteoporosis - blood ; Osteoporosis - diagnosis ; Osteoporosis - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Osteoprotegerin - blood ; Postmenopause - physiology ; Premenopause - physiology ; ROC Curve ; Women</subject><ispartof>Journal of bone and mineral metabolism, 2008-03, Vol.26 (2), p.159-164</ispartof><rights>Springer Japan 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-c0cdeaa5bc069d421fd90f469627a47a1c00f510d83a77f0eefa22bebf8756353</citedby><cites>FETCH-LOGICAL-c519t-c0cdeaa5bc069d421fd90f469627a47a1c00f510d83a77f0eefa22bebf8756353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-007-0799-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-007-0799-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20086747$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18301972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jian-min</creatorcontrib><creatorcontrib>Zhao, Hong-yan</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Zhang, Lian-zhen</creatorcontrib><creatorcontrib>Sun, Li-hao</creatorcontrib><creatorcontrib>Zhao, Yong-ju</creatorcontrib><creatorcontrib>Xu, Man-yin</creatorcontrib><creatorcontrib>Chen, Jia-lun</creatorcontrib><title>IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>To find out which of the following parameters—serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for osteopenia/osteoporosis in women diagnosed by dual-energy X-ray absorptiometry (DXA), 282 premenopausal and 222 postmenopausal women aged 20–75 years were investigated by the measurement of bone mineral densities (BMDs) at lumbar spine (LS) and femoral neck (FN) by DXA, together with serum concentrations of IGF-1, OPG, leptin, OC, and urinary NTx. The characteristics of the earliest marker(s) were tested with the receiver operating characteristic (ROC) analysis. The area under the curve (AUC), sensitivity, and specificity parameters were determined. It was revealed that serum levels of IGF-1 and leptin changed the earliest, with both markers significantly decreasing (
P
< 0.0001) or increasing (
P
= 0.020), respectively, at age 30. However, in ROC analysis, IGF-1 was the only early parameter that had the capacity to differentiate the low bone mass/osteoporosis women from the normal ones (
P
< 0.0001). If the serum level of IGF-1 at 1.5 SD below its peak was adopted as a cutoff point, it could identify women with low bone mass/osteoporosis with a sensitivity of 73% and specificity of 67%. In the premenopausal women subgroup analysis, the low bone mass women (30/282, 10.6%) were older (38.2 ± 1.7 vs. 34.5 ± 0.5 years;
P
= 0.026), with lower serum levels of IGF-1 (215.1 ± 22.4 vs. 278.8 ± 9.4 ng/ml;
P
= 0.02) and less lean mass (33.1 ± 0.6 vs. 34.8 ± 0.2 kg;
P
= 0.010) than the normal ones. After controlling for age, the serum level of IGF-1 had a weak, but still significant, positive correlation with lean mass (
r
= 0.17,
P
< 0.001). In conclusion, measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aging</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Density</subject><subject>Bones</subject><subject>Cytokines - blood</subject><subject>Diagnosis, Differential</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Femur Neck - physiopathology</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-like growth factors</subject><subject>Leptin - blood</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporosis - blood</subject><subject>Osteoporosis - diagnosis</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Osteoprotegerin - blood</subject><subject>Postmenopause - physiology</subject><subject>Premenopause - physiology</subject><subject>ROC Curve</subject><subject>Women</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMFOwzAMhiMEYmPwAFxQJMQxYLdJ0xzRxMakSVzgXKVtgja6piSrpu3pybQJduHixM7n3_FPyC3CIwLIpxCD5CxGBlIptjsjQ-SpYCIDfk6GoJCzXEo1IFchLAFQComXZIB5CqhkMiT1bDphSHWguqVG-2ZLV9p_GU-t87RxG1q61sRaCDQWXFgb1znvwiLQRUs7b1amdZ3ug26iRE27iJyUNi4m1-TC6iaYm-M5Ih-Tl_fxK5u_TWfj5zmrBKo1q6CqjdairCBTNU_Q1gosz1SWSM2lxgrACoQ6T7WUFoyxOklKU9pciiwV6YjcH3Q77757E9bF0vW-jSMLREw5T6XASOGBquIawRtbdH4Rl94WCMXe1-Lga7G_7n0tdrHn7qjclytT_3UcjYzAwxHQodKN9bqtFuGXSwDyTHIZueTAhfjUfhp_8sV_p_8AENORIA</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Liu, Jian-min</creator><creator>Zhao, Hong-yan</creator><creator>Ning, Guang</creator><creator>Chen, Ying</creator><creator>Zhang, Lian-zhen</creator><creator>Sun, Li-hao</creator><creator>Zhao, Yong-ju</creator><creator>Xu, Man-yin</creator><creator>Chen, Jia-lun</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20080301</creationdate><title>IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women</title><author>Liu, Jian-min ; Zhao, Hong-yan ; Ning, Guang ; Chen, Ying ; Zhang, Lian-zhen ; Sun, Li-hao ; Zhao, Yong-ju ; Xu, Man-yin ; Chen, Jia-lun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-c0cdeaa5bc069d421fd90f469627a47a1c00f510d83a77f0eefa22bebf8756353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aging</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Bone and Bones - physiopathology</topic><topic>Bone Density</topic><topic>Bones</topic><topic>Cytokines - blood</topic><topic>Diagnosis, Differential</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Femur Neck - physiopathology</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-like growth factors</topic><topic>Leptin - blood</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporosis - blood</topic><topic>Osteoporosis - diagnosis</topic><topic>Osteoporosis - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Osteoprotegerin - blood</topic><topic>Postmenopause - physiology</topic><topic>Premenopause - physiology</topic><topic>ROC Curve</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jian-min</creatorcontrib><creatorcontrib>Zhao, Hong-yan</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Zhang, Lian-zhen</creatorcontrib><creatorcontrib>Sun, Li-hao</creatorcontrib><creatorcontrib>Zhao, Yong-ju</creatorcontrib><creatorcontrib>Xu, Man-yin</creatorcontrib><creatorcontrib>Chen, Jia-lun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jian-min</au><au>Zhao, Hong-yan</au><au>Ning, Guang</au><au>Chen, Ying</au><au>Zhang, Lian-zhen</au><au>Sun, Li-hao</au><au>Zhao, Yong-ju</au><au>Xu, Man-yin</au><au>Chen, Jia-lun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>26</volume><issue>2</issue><spage>159</spage><epage>164</epage><pages>159-164</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>To find out which of the following parameters—serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for osteopenia/osteoporosis in women diagnosed by dual-energy X-ray absorptiometry (DXA), 282 premenopausal and 222 postmenopausal women aged 20–75 years were investigated by the measurement of bone mineral densities (BMDs) at lumbar spine (LS) and femoral neck (FN) by DXA, together with serum concentrations of IGF-1, OPG, leptin, OC, and urinary NTx. The characteristics of the earliest marker(s) were tested with the receiver operating characteristic (ROC) analysis. The area under the curve (AUC), sensitivity, and specificity parameters were determined. It was revealed that serum levels of IGF-1 and leptin changed the earliest, with both markers significantly decreasing (
P
< 0.0001) or increasing (
P
= 0.020), respectively, at age 30. However, in ROC analysis, IGF-1 was the only early parameter that had the capacity to differentiate the low bone mass/osteoporosis women from the normal ones (
P
< 0.0001). If the serum level of IGF-1 at 1.5 SD below its peak was adopted as a cutoff point, it could identify women with low bone mass/osteoporosis with a sensitivity of 73% and specificity of 67%. In the premenopausal women subgroup analysis, the low bone mass women (30/282, 10.6%) were older (38.2 ± 1.7 vs. 34.5 ± 0.5 years;
P
= 0.026), with lower serum levels of IGF-1 (215.1 ± 22.4 vs. 278.8 ± 9.4 ng/ml;
P
= 0.02) and less lean mass (33.1 ± 0.6 vs. 34.8 ± 0.2 kg;
P
= 0.010) than the normal ones. After controlling for age, the serum level of IGF-1 had a weak, but still significant, positive correlation with lean mass (
r
= 0.17,
P
< 0.001). In conclusion, measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>18301972</pmid><doi>10.1007/s00774-007-0799-z</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of bone and mineral metabolism, 2008-03, Vol.26 (2), p.159-164 |
| issn | 0914-8779 1435-5604 |
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| subjects | Adult Age Distribution Aged Aging Area Under Curve Biological and medical sciences Biomarkers - blood Bone and Bones - physiopathology Bone Density Bones Cytokines - blood Diagnosis, Differential Diseases of the osteoarticular system Female Femur Neck - physiopathology Humans Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Leptin - blood Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Organ Size Original Article Orthopedics Osteoporosis Osteoporosis - blood Osteoporosis - diagnosis Osteoporosis - physiopathology Osteoporosis. Osteomalacia. Paget disease Osteoprotegerin - blood Postmenopause - physiology Premenopause - physiology ROC Curve Women |
| title | IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women |
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