Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial
Introduction Roux-en-Y gastric bypass (RNYGB) surgery offers an effective and enduring treatment for morbid obesity. Gastric bypass may alter gastrointestinal (GI) flora possibly resulting in bacterial overgrowth and dysmotility. Our hypothesis was that daily use of probiotics would improve GI outco...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2009-07, Vol.13 (7), p.1198-1204 |
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| creator | Woodard, Gavitt A. Encarnacion, Betsy Downey, John R. Peraza, Joseph Chong, Karen Hernandez-Boussard, Tina Morton, John M. |
| description | Introduction
Roux-en-Y gastric bypass (RNYGB) surgery offers an effective and enduring treatment for morbid obesity. Gastric bypass may alter gastrointestinal (GI) flora possibly resulting in bacterial overgrowth and dysmotility. Our hypothesis was that daily use of probiotics would improve GI outcomes after RNYGB.
Methods
Forty-four patients undergoing RNYGB were randomized to either a probiotic or control group; 2.4 billion colonies of
Lactobacillus
were administered daily postoperatively to the probiotic group. The outcomes of H
2
levels indicative of bacterial overgrowth, GI-related quality of life (GIQoL), serologies, and weight loss were measured preoperatively and at 3 and 6 months postoperatively. Categorical variables were analyzed by
χ
2
test and continuous variables were analyzed by
t
test with a
p
|
| doi_str_mv | 10.1007/s11605-009-0891-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1112236183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2789655441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-2369382d36a4e1b638733660177e53d0f88e3a03d035c0b8faac3f3f76de50da3</originalsourceid><addsrcrecordid>eNp1kEFLw0AQhRdRbK3-AC-y4Hl1JttsUm-1aC0UKrWCnpZNspGUpqm7ibT-eqekoBdPO-y8efPmY-wS4QYBoluPqCAUAAMB8QDF9oh1MY6k6KtAHVMN9BmE4VuHnXm_BMAIMD5lHRzIGCMZdlny7KqkqOoi9XxSblz1ZfmsqdOqtJ4P89o6Pq-arbBr8c7HxteuSPn9bmO85y-N-7Bud8eHnFz8xqZ1QeNzs86qsvi2GV-4wqzO2UluVt5eHN4ee318WIyexHQ2noyGU5HKCGoRSEWpgkwq07eYKEmHSKUoc2RDmUEex1YaoEqGKSRxbkwqc5lHKrMhZEb22HXrS1d8NtbXelk1bk0rNSIG5I-xJBW2qpQie2dzvXFFadxOI-g9Vd1S1URV76nqLc1cHZybpLTZ78QBIwmCVuCptSYof1b_6_oDRjiCiQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1112236183</pqid></control><display><type>article</type><title>Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Woodard, Gavitt A. ; Encarnacion, Betsy ; Downey, John R. ; Peraza, Joseph ; Chong, Karen ; Hernandez-Boussard, Tina ; Morton, John M.</creator><creatorcontrib>Woodard, Gavitt A. ; Encarnacion, Betsy ; Downey, John R. ; Peraza, Joseph ; Chong, Karen ; Hernandez-Boussard, Tina ; Morton, John M.</creatorcontrib><description>Introduction
Roux-en-Y gastric bypass (RNYGB) surgery offers an effective and enduring treatment for morbid obesity. Gastric bypass may alter gastrointestinal (GI) flora possibly resulting in bacterial overgrowth and dysmotility. Our hypothesis was that daily use of probiotics would improve GI outcomes after RNYGB.
Methods
Forty-four patients undergoing RNYGB were randomized to either a probiotic or control group; 2.4 billion colonies of
Lactobacillus
were administered daily postoperatively to the probiotic group. The outcomes of H
2
levels indicative of bacterial overgrowth, GI-related quality of life (GIQoL), serologies, and weight loss were measured preoperatively and at 3 and 6 months postoperatively. Categorical variables were analyzed by
χ
2
test and continuous variables were analyzed by
t
test with a
p
< 0.05 for significance.
Results
At 6 months, a statistically significant reduction in bacterial overgrowth was achieved in the probiotic group with a preoperative to postoperative change of sum H
2
part per million (probiotics = −32.13, controls = 0.80). Surprisingly, the probiotic group attained significantly greater percent excess weight loss than that of control group at 6 weeks (controls = 25.5%, probiotic = 29.9%) and 3 months (38.55%, 47.68%). This trend also continued but was not significant at 6 months (60.78%, 67.15%). The probiotic group had significantly higher postoperative vitamin B12 levels than the control group. Both probiotic and control groups significantly improved their GIQoL.
Conclusion
In this novel study, probiotic administration improves bacterial overgrowth, vitamin B12 availability, and weight loss after RNYGB. These data may provide further evidence that altering the GI microbiota can influence weight loss.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-009-0891-x</identifier><identifier>PMID: 19381735</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>2008 SSAT Plenery Presentation ; Adult ; Body Mass Index ; Confidence Intervals ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Gastric Bypass - adverse effects ; Gastric Bypass - methods ; Gastroenterology ; Gastrointestinal surgery ; Heart surgery ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity, Morbid - diagnosis ; Obesity, Morbid - drug therapy ; Obesity, Morbid - surgery ; Patient Satisfaction ; Postoperative Care - methods ; Postoperative Complications - prevention & control ; Probability ; Probiotics ; Probiotics - therapeutic use ; Prospective Studies ; Reference Values ; Risk Assessment ; Surgery ; Treatment Outcome ; Weight control ; Weight Loss</subject><ispartof>Journal of gastrointestinal surgery, 2009-07, Vol.13 (7), p.1198-1204</ispartof><rights>The Society for Surgery of the Alimentary Tract 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-2369382d36a4e1b638733660177e53d0f88e3a03d035c0b8faac3f3f76de50da3</citedby><cites>FETCH-LOGICAL-c370t-2369382d36a4e1b638733660177e53d0f88e3a03d035c0b8faac3f3f76de50da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-009-0891-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-009-0891-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19381735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woodard, Gavitt A.</creatorcontrib><creatorcontrib>Encarnacion, Betsy</creatorcontrib><creatorcontrib>Downey, John R.</creatorcontrib><creatorcontrib>Peraza, Joseph</creatorcontrib><creatorcontrib>Chong, Karen</creatorcontrib><creatorcontrib>Hernandez-Boussard, Tina</creatorcontrib><creatorcontrib>Morton, John M.</creatorcontrib><title>Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Introduction
Roux-en-Y gastric bypass (RNYGB) surgery offers an effective and enduring treatment for morbid obesity. Gastric bypass may alter gastrointestinal (GI) flora possibly resulting in bacterial overgrowth and dysmotility. Our hypothesis was that daily use of probiotics would improve GI outcomes after RNYGB.
Methods
Forty-four patients undergoing RNYGB were randomized to either a probiotic or control group; 2.4 billion colonies of
Lactobacillus
were administered daily postoperatively to the probiotic group. The outcomes of H
2
levels indicative of bacterial overgrowth, GI-related quality of life (GIQoL), serologies, and weight loss were measured preoperatively and at 3 and 6 months postoperatively. Categorical variables were analyzed by
χ
2
test and continuous variables were analyzed by
t
test with a
p
< 0.05 for significance.
Results
At 6 months, a statistically significant reduction in bacterial overgrowth was achieved in the probiotic group with a preoperative to postoperative change of sum H
2
part per million (probiotics = −32.13, controls = 0.80). Surprisingly, the probiotic group attained significantly greater percent excess weight loss than that of control group at 6 weeks (controls = 25.5%, probiotic = 29.9%) and 3 months (38.55%, 47.68%). This trend also continued but was not significant at 6 months (60.78%, 67.15%). The probiotic group had significantly higher postoperative vitamin B12 levels than the control group. Both probiotic and control groups significantly improved their GIQoL.
Conclusion
In this novel study, probiotic administration improves bacterial overgrowth, vitamin B12 availability, and weight loss after RNYGB. These data may provide further evidence that altering the GI microbiota can influence weight loss.</description><subject>2008 SSAT Plenery Presentation</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>Confidence Intervals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric Bypass - adverse effects</subject><subject>Gastric Bypass - methods</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity, Morbid - diagnosis</subject><subject>Obesity, Morbid - drug therapy</subject><subject>Obesity, Morbid - surgery</subject><subject>Patient Satisfaction</subject><subject>Postoperative Care - methods</subject><subject>Postoperative Complications - prevention & control</subject><subject>Probability</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEFLw0AQhRdRbK3-AC-y4Hl1JttsUm-1aC0UKrWCnpZNspGUpqm7ibT-eqekoBdPO-y8efPmY-wS4QYBoluPqCAUAAMB8QDF9oh1MY6k6KtAHVMN9BmE4VuHnXm_BMAIMD5lHRzIGCMZdlny7KqkqOoi9XxSblz1ZfmsqdOqtJ4P89o6Pq-arbBr8c7HxteuSPn9bmO85y-N-7Bud8eHnFz8xqZ1QeNzs86qsvi2GV-4wqzO2UluVt5eHN4ee318WIyexHQ2noyGU5HKCGoRSEWpgkwq07eYKEmHSKUoc2RDmUEex1YaoEqGKSRxbkwqc5lHKrMhZEb22HXrS1d8NtbXelk1bk0rNSIG5I-xJBW2qpQie2dzvXFFadxOI-g9Vd1S1URV76nqLc1cHZybpLTZ78QBIwmCVuCptSYof1b_6_oDRjiCiQ</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Woodard, Gavitt A.</creator><creator>Encarnacion, Betsy</creator><creator>Downey, John R.</creator><creator>Peraza, Joseph</creator><creator>Chong, Karen</creator><creator>Hernandez-Boussard, Tina</creator><creator>Morton, John M.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20090701</creationdate><title>Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial</title><author>Woodard, Gavitt A. ; Encarnacion, Betsy ; Downey, John R. ; Peraza, Joseph ; Chong, Karen ; Hernandez-Boussard, Tina ; Morton, John M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-2369382d36a4e1b638733660177e53d0f88e3a03d035c0b8faac3f3f76de50da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>2008 SSAT Plenery Presentation</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>Confidence Intervals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric Bypass - adverse effects</topic><topic>Gastric Bypass - methods</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity, Morbid - diagnosis</topic><topic>Obesity, Morbid - drug therapy</topic><topic>Obesity, Morbid - surgery</topic><topic>Patient Satisfaction</topic><topic>Postoperative Care - methods</topic><topic>Postoperative Complications - prevention & control</topic><topic>Probability</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woodard, Gavitt A.</creatorcontrib><creatorcontrib>Encarnacion, Betsy</creatorcontrib><creatorcontrib>Downey, John R.</creatorcontrib><creatorcontrib>Peraza, Joseph</creatorcontrib><creatorcontrib>Chong, Karen</creatorcontrib><creatorcontrib>Hernandez-Boussard, Tina</creatorcontrib><creatorcontrib>Morton, John M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woodard, Gavitt A.</au><au>Encarnacion, Betsy</au><au>Downey, John R.</au><au>Peraza, Joseph</au><au>Chong, Karen</au><au>Hernandez-Boussard, Tina</au><au>Morton, John M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>13</volume><issue>7</issue><spage>1198</spage><epage>1204</epage><pages>1198-1204</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Introduction
Roux-en-Y gastric bypass (RNYGB) surgery offers an effective and enduring treatment for morbid obesity. Gastric bypass may alter gastrointestinal (GI) flora possibly resulting in bacterial overgrowth and dysmotility. Our hypothesis was that daily use of probiotics would improve GI outcomes after RNYGB.
Methods
Forty-four patients undergoing RNYGB were randomized to either a probiotic or control group; 2.4 billion colonies of
Lactobacillus
were administered daily postoperatively to the probiotic group. The outcomes of H
2
levels indicative of bacterial overgrowth, GI-related quality of life (GIQoL), serologies, and weight loss were measured preoperatively and at 3 and 6 months postoperatively. Categorical variables were analyzed by
χ
2
test and continuous variables were analyzed by
t
test with a
p
< 0.05 for significance.
Results
At 6 months, a statistically significant reduction in bacterial overgrowth was achieved in the probiotic group with a preoperative to postoperative change of sum H
2
part per million (probiotics = −32.13, controls = 0.80). Surprisingly, the probiotic group attained significantly greater percent excess weight loss than that of control group at 6 weeks (controls = 25.5%, probiotic = 29.9%) and 3 months (38.55%, 47.68%). This trend also continued but was not significant at 6 months (60.78%, 67.15%). The probiotic group had significantly higher postoperative vitamin B12 levels than the control group. Both probiotic and control groups significantly improved their GIQoL.
Conclusion
In this novel study, probiotic administration improves bacterial overgrowth, vitamin B12 availability, and weight loss after RNYGB. These data may provide further evidence that altering the GI microbiota can influence weight loss.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>19381735</pmid><doi>10.1007/s11605-009-0891-x</doi><tpages>7</tpages></addata></record> |
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| subjects | 2008 SSAT Plenery Presentation Adult Body Mass Index Confidence Intervals Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Gastric Bypass - adverse effects Gastric Bypass - methods Gastroenterology Gastrointestinal surgery Heart surgery Humans Male Medicine Medicine & Public Health Middle Aged Obesity, Morbid - diagnosis Obesity, Morbid - drug therapy Obesity, Morbid - surgery Patient Satisfaction Postoperative Care - methods Postoperative Complications - prevention & control Probability Probiotics Probiotics - therapeutic use Prospective Studies Reference Values Risk Assessment Surgery Treatment Outcome Weight control Weight Loss |
| title | Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial |
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