Safety and pharmacokinetic study of nab-paclitaxel plus carboplatin in chemotherapy-naïve patients with advanced non–small cell lung cancer

Summary Background Nanoparticle albumin-bound paclitaxel ( nab -paclitaxel) is a Cremophor EL–free formulation of paclitaxel newly designed to avoid solvent-related toxicities. We have evaluated the safety, tolerability, pharmacokinetics, and tumor response profile of weekly nab -paclitaxel (100 mg/...

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Veröffentlicht in:	Investigational new drugs 2012-06, Vol.30 (3), p.1132-1137
Hauptverfasser:	Okamoto, Isamu, Yamamoto, Nobuyuki, Kubota, Kaoru, Ohe, Yuichiro, Nogami, Naoyuki, Murakami, Haruyasu, Yamaya, Hidetoshi, Ono, Katsuhiro, Nakagawa, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Albumins - administration & dosage Albumins - adverse effects Albumins - pharmacokinetics Alopecia Anemia Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Area Under Curve Asian Continental Ancestry Group Baldness Cancer therapies Carboplatin - administration & dosage Carboplatin - adverse effects Carboplatin - pharmacokinetics Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Chemotherapy Drug dosages Female Histamine Hospitals Humans Leukopenia Lung cancer Male Medicine Medicine & Public Health Middle Aged Nanoparticles Neutropenia Oncology Paclitaxel - administration & dosage Paclitaxel - adverse effects Paclitaxel - pharmacokinetics Patient safety Peripheral neuropathy Pharmacokinetics Pharmacology Pharmacology/Toxicology Phase I Studies Response rates Solvents Steroids Studies Tumors
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