CYT997 Causes apoptosis in human multiple myeloma

Summary Multiple Myeloma (MM) is an incurable malignancy of mature plasma cells. Microtubule targeting agents (MTAs) are an established class of drug that include many conventional and some novel compounds. MTAs function by inhibiting the polymerisation or depolymerisation of microtubules (MTs) with...

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Veröffentlicht in:	Investigational new drugs 2011-04, Vol.29 (2), p.232-238
Hauptverfasser:	Monaghan, Katherine, Khong, Tiffany, Smith, Gregg, Spencer, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Boronic Acids - pharmacology Bortezomib Cancer Cell cycle Cell division Cell growth Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor Drug Synergism Drugs Fluorescent Antibody Technique G2 Phase - drug effects Hematology Humans Medicine Medicine & Public Health Mice Mitosis - drug effects Multiple myeloma Multiple Myeloma - pathology Oncology Penicillin Pharmaceuticals Pharmacology/Toxicology Polymerization - drug effects Preclinical Studies Pyrazines - pharmacology Pyridines - pharmacology Pyrimidines - pharmacology R&D Research & development Survival Analysis Time Factors Tubulin - metabolism
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