Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma

Summary Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches, notably chemoprevention, have been considered t...

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Veröffentlicht in:	Investigational new drugs 2011-04, Vol.29 (2), p.380-391
Hauptverfasser:	Luther, Daniel J., Ohanyan, Vahagn, Shamhart, Patricia E., Hodnichak, Cheryl M., Sisakian, Hamayak, Booth, Tristan D., Meszaros, J. Gary, Bishayee, Anupam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Behavior, Animal - drug effects Blotting, Western Cancer therapies Candidates Carcinogens Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - physiopathology Cardiac function Cardiotoxicity Cardiotoxins - toxicity Chemoprevention Colleges & universities Disease Models, Animal Disease prevention Dose-Response Relationship, Drug Drug dosages Echocardiography Feeding Behavior - drug effects Female Heart - drug effects Heart - physiopathology Hepatocytes - drug effects Hepatocytes - pathology Humans Liver - drug effects Liver - pathology Liver - physiopathology Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver Neoplasms - physiopathology Medical prognosis Medicine Medicine & Public Health Oncology Pharmaceuticals Pharmacology/Toxicology Pharmacy Phytochemicals R&D Rats Rats, Sprague-Dawley Research & development Rodents Short Report Stilbenes - therapeutic use Systole - drug effects
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