Mesenchymal Stem Cells Provide an Advantageous Tumor Microenvironment for the Restoration of Cancer Stem Cells

Objective: Accumulating evidences suggest that cancer-associated fibroblasts are provided from bone-marrow-derived mesenchymal stem cells (BM-MSCs); however, little is known about the mechanism(s) by which BM-MSCs accelerate cancer aggressiveness. Methods: Gastric carcinoma (GC)-derived MKN-7 cells...

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Veröffentlicht in:	Pathobiology (Basel) 2012-07, Vol.79 (6), p.290-306
Hauptverfasser:	Nishimura, Kanako, Semba, Shuho, Aoyagi, Kazuhiko, Sasaki, Hiroki, Yokozaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Bone marrow Cancer Cell Line, Tumor Cell Proliferation Disease Models, Animal Gene Expression Profiling Humans Immunohistochemistry Male Medical research Mesenchymal Stromal Cells - physiology Mice Mice, SCID Microenvironments Mouse mammary tumor virus Neoplastic Stem Cells - physiology Oligonucleotide Array Sequence Analysis Original Paper Pathology Reverse Transcriptase Polymerase Chain Reaction Stem cells Transforming Growth Factor beta - genetics Tumor Microenvironment Tumors Up-Regulation - genetics Wnt Proteins - genetics Wnt-5a Protein
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