Antagonism of convulsions but failure to enhance GABAA receptor function by felbamate in mice tolerant to diazepam

The transfer of tolerance between drugs may indicate a common mode of action. The development of cross-tolerance to the anticonvulsant effect of felbamate after long-term treatment of mice with diazepam, a positive modulator of γ-aminobutyric acid (GABA)-mediated transmission, was therefore studied...

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Veröffentlicht in:Neurochemical research 1997-06, Vol.22 (6), p.693-697
Hauptverfasser: SERRA, M, CUCCU, R, GHIANI, C. A, PISU, M. G, MURGIA, A, BIGGIO, G
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Sprache:eng
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