Primary Ewing Sarcoma of the Stomach – A Newly Described Entity
The Ewing sarcoma family of tumors (ESFT) includes classic Ewing sarcoma of the bone, extraosseous or soft tissue Ewing sarcoma, Askin tumors of the chest wall, and peripheral primitive neuroectodermal tumors of the bone and soft tissues. They share a common neural histogenesis, tumor genetics and b...
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| Veröffentlicht in: | European surgical research 2009-01, Vol.42 (1), p.17-20 |
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| creator | Rafailidis, S. Ballas, K. Psarras, K. Pavlidis, T. Symeonidis, N. Marakis, G. Sakadamis, A. |
| description | The Ewing sarcoma family of tumors (ESFT) includes classic Ewing sarcoma of the bone, extraosseous or soft tissue Ewing sarcoma, Askin tumors of the chest wall, and peripheral primitive neuroectodermal tumors of the bone and soft tissues. They share a common neural histogenesis, tumor genetics and biology. The genetic hallmark of the ESFT is the presence of t(11;22)(q24;q12), which creates the EWS/FLI1 fusion gene and results in the expression of a chimeric protein. Although Ewing tumors can occur at any age, the great majority are found in individuals less than 20 years of age. We herein report a case of gastric Ewing sarcoma in a 68-year-old male. This patient illustrates the second reported occurrence of primary Ewing sarcoma in the stomach and the first reported with the t(11;22)(q24;q12) gene translocation. |
| doi_str_mv | 10.1159/000166166 |
| format | Article |
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| subjects | 12E7 Antigen Aged Antigens, CD - metabolism Case Report Cell Adhesion Molecules - metabolism Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 22 - genetics Humans Male Oncogene Proteins, Fusion - genetics Proto-Oncogene Protein c-fli-1 - genetics RNA-Binding Protein EWS Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Translocation, Genetic |
| title | Primary Ewing Sarcoma of the Stomach – A Newly Described Entity |
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