Electrolyte-Stimulated Biphasic Dissolution Profile and Stability Enhancement for Tablets Containing Drug-Polyelectrolyte Complexes

Purpose Recently introduced drug-polyelectrolyte complexes prepared by hot-melt extrusion should be processed to solid dosage forms with tailor-made release properties. Their potential of stability enhancement should be investigated. Methods Milled hot-melt extruded naproxen-EUDRAGIT® E PO polyelect...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical research 2012-10, Vol.29 (10), p.2710-2721
Hauptverfasser:	Kindermann, Christoph, Matthée, Karin, Sievert, Frank, Breitkreutz, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical - methods Delayed-Action Preparations - chemistry Dissolution Dosage Forms Drug delivery systems Drug Stability Electrolytes Electrolytes - chemistry Hydrogen-Ion Concentration Medical Law Naproxen - chemistry Pharmaceutical Preparations - chemistry Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Research Paper Theme: Physicochem Interactions Solubility Tablets - chemistry Technology, Pharmaceutical - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!