Investigating the involvement of the ATF6[alpha] pathway of the unfolded protein response in adipogenesis

The unfolded protein response (UPR) is activated by endoplasmic reticulum stress resulting from an accumulation of unfolded or mis-folded proteins. The UPR is divided into three arms, involving the activation of ATF-6, PERK and IRE-1, that together act to restrict new protein synthesis and increase...

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Veröffentlicht in:	International Journal of Obesity 2012-09, Vol.36 (9), p.1248
Hauptverfasser:	Lowe, C E, Dennis, R J, Obi, U, O'rahilly, S, Rochford, J J
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adipocytes Body fat Endoplasmic reticulum Kinases Laboratories Lipids Metabolism Obesity Pathophysiology Protein synthesis Proteins Transcription factors
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