B024: Increased muscle sympathetic nerve activity contributes to disturbed large artery distensibility in renal transplant patients
In renal transplant recipients (RTX) both increased sympathetic nerve activity and disturbed mechanical vessel wall properties of large arteries are observed. To investigate a possible relation between the two, we measured in RTX receiving cyclosporine (RTX-CSA, n=16) or tacrolimus (RTX-FK, n=16) an...
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| Veröffentlicht in: | American journal of hypertension 2000-04, Vol.13 (S2), p.195A-195A |
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| container_title | American journal of hypertension |
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| creator | Barenbrock, M. Hausberg, M. Kosch, M. Posadzy-Malaczyns-ka, A. Kisters, K. Rahn, K.H. |
| description | In renal transplant recipients (RTX) both increased sympathetic nerve activity and disturbed mechanical vessel wall properties of large arteries are observed. To investigate a possible relation between the two, we measured in RTX receiving cyclosporine (RTX-CSA, n=16) or tacrolimus (RTX-FK, n=16) and in healthy volunteers (CTR, n=10) blood pressure (MAP, automatic sphygmomanometer), muscle sympathetic nerve activity (MSNA, microneurography) and distensibility coefficients of the brachial and carotid arteries (DC bra, DC car, pulsed doppler). Data are mean±SEM. There was a significant correlation between DC bra and MSNA (r=−0.46, p |
| doi_str_mv | 10.1016/S0895-7061(00)00685-3 |
| format | Article |
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To investigate a possible relation between the two, we measured in RTX receiving cyclosporine (RTX-CSA, n=16) or tacrolimus (RTX-FK, n=16) and in healthy volunteers (CTR, n=10) blood pressure (MAP, automatic sphygmomanometer), muscle sympathetic nerve activity (MSNA, microneurography) and distensibility coefficients of the brachial and carotid arteries (DC bra, DC car, pulsed doppler). Data are mean±SEM. There was a significant correlation between DC bra and MSNA (r=−0.46, p<0.01), but not between DC car and MSNA (r=−0.16, n.s.). The correlation between DC bra and MSNA remained statistically significant on separate analysis of RTX-CSA and RTX-FK and after correction for arterial diameter, blood pressure, graft function, age, sex and smoking habits by stepwise multiple regression analysis. (See Table and Figure) Group RTX CTR MAP (mmHg) 103 ± 2* 86 ± 3 DC car (10-3/kPa) 17 ± 1* 26 ± 1 DC bra (10-3/kPa) 7 ± 1* 12 ± 1 MSNA (bursts/min) 36 ± 3* 16 ± 4 *p<0.05 vs. CTR. The results show that increased sympathetic nerve activity in RTX can adversely influence mechanical vessel wall properties of muscular type arteries. In contrast, the results failed to demonstrate an effect of MSNA on mechanical properties of elastic type arteries.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1016/S0895-7061(00)00685-3</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>arterial distensibility ; Renal transplantation ; sympathetic nervous system</subject><ispartof>American journal of hypertension, 2000-04, Vol.13 (S2), p.195A-195A</ispartof><rights>Copyright Nature Publishing Group Apr 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Barenbrock, M.</creatorcontrib><creatorcontrib>Hausberg, M.</creatorcontrib><creatorcontrib>Kosch, M.</creatorcontrib><creatorcontrib>Posadzy-Malaczyns-ka, A.</creatorcontrib><creatorcontrib>Kisters, K.</creatorcontrib><creatorcontrib>Rahn, K.H.</creatorcontrib><title>B024: Increased muscle sympathetic nerve activity contributes to disturbed large artery distensibility in renal transplant patients</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>In renal transplant recipients (RTX) both increased sympathetic nerve activity and disturbed mechanical vessel wall properties of large arteries are observed. To investigate a possible relation between the two, we measured in RTX receiving cyclosporine (RTX-CSA, n=16) or tacrolimus (RTX-FK, n=16) and in healthy volunteers (CTR, n=10) blood pressure (MAP, automatic sphygmomanometer), muscle sympathetic nerve activity (MSNA, microneurography) and distensibility coefficients of the brachial and carotid arteries (DC bra, DC car, pulsed doppler). Data are mean±SEM. There was a significant correlation between DC bra and MSNA (r=−0.46, p<0.01), but not between DC car and MSNA (r=−0.16, n.s.). The correlation between DC bra and MSNA remained statistically significant on separate analysis of RTX-CSA and RTX-FK and after correction for arterial diameter, blood pressure, graft function, age, sex and smoking habits by stepwise multiple regression analysis. (See Table and Figure) Group RTX CTR MAP (mmHg) 103 ± 2* 86 ± 3 DC car (10-3/kPa) 17 ± 1* 26 ± 1 DC bra (10-3/kPa) 7 ± 1* 12 ± 1 MSNA (bursts/min) 36 ± 3* 16 ± 4 *p<0.05 vs. CTR. The results show that increased sympathetic nerve activity in RTX can adversely influence mechanical vessel wall properties of muscular type arteries. In contrast, the results failed to demonstrate an effect of MSNA on mechanical properties of elastic type arteries.</description><subject>arterial distensibility</subject><subject>Renal transplantation</subject><subject>sympathetic nervous system</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpF0EtLw0AQAOBFFKzVnyAseNFDdCbJPuJNg7aFoqA9iJewSTd2a7qtu5tiz_5xUyt6Ghi-eRJyinCJgPzqGWTGIgEczwEuALhkUbJHepilGIk4Zvuk90cOyZH3cwBIOcce-bqFOL2mI1s5rbye0kXrq0ZTv1msVJjpYCpqtVtrqqpg1iZsaLW0wZmyDdrTsKRT40Pryq60Ue6tcy5ot_lJa-tNaZptkbHUaasaGpyyftUoG2g3wGgb_DE5qFXj9clv7JPJ_d0kH0bjx8EovxlHJkOMaoFS8IRJZFWFWVarVFZMsVQJIXhcKkABWV2KspzKGAVTJUAtBHJRT9M4S_rkbNd25ZYfrfahmC9b1-3kC4REYspQYqfoTlnVnaWLlTML5TaFms_i7msCZEeiHdme-Pkv3HvBRSJYMXx5LdhTNsgfcigekm99AH7B</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>Barenbrock, M.</creator><creator>Hausberg, M.</creator><creator>Kosch, M.</creator><creator>Posadzy-Malaczyns-ka, A.</creator><creator>Kisters, K.</creator><creator>Rahn, K.H.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200004</creationdate><title>B024: Increased muscle sympathetic nerve activity contributes to disturbed large artery distensibility in renal transplant patients</title><author>Barenbrock, M. ; Hausberg, M. ; Kosch, M. ; Posadzy-Malaczyns-ka, A. ; Kisters, K. ; Rahn, K.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i911-f7187635815cc199fa48c5a54a77762ba01709fb7bbd82175ab00f77167fd4293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>arterial distensibility</topic><topic>Renal transplantation</topic><topic>sympathetic nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barenbrock, M.</creatorcontrib><creatorcontrib>Hausberg, M.</creatorcontrib><creatorcontrib>Kosch, M.</creatorcontrib><creatorcontrib>Posadzy-Malaczyns-ka, A.</creatorcontrib><creatorcontrib>Kisters, K.</creatorcontrib><creatorcontrib>Rahn, K.H.</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barenbrock, M.</au><au>Hausberg, M.</au><au>Kosch, M.</au><au>Posadzy-Malaczyns-ka, A.</au><au>Kisters, K.</au><au>Rahn, K.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B024: Increased muscle sympathetic nerve activity contributes to disturbed large artery distensibility in renal transplant patients</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2000-04</date><risdate>2000</risdate><volume>13</volume><issue>S2</issue><spage>195A</spage><epage>195A</epage><pages>195A-195A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>In renal transplant recipients (RTX) both increased sympathetic nerve activity and disturbed mechanical vessel wall properties of large arteries are observed. To investigate a possible relation between the two, we measured in RTX receiving cyclosporine (RTX-CSA, n=16) or tacrolimus (RTX-FK, n=16) and in healthy volunteers (CTR, n=10) blood pressure (MAP, automatic sphygmomanometer), muscle sympathetic nerve activity (MSNA, microneurography) and distensibility coefficients of the brachial and carotid arteries (DC bra, DC car, pulsed doppler). Data are mean±SEM. There was a significant correlation between DC bra and MSNA (r=−0.46, p<0.01), but not between DC car and MSNA (r=−0.16, n.s.). The correlation between DC bra and MSNA remained statistically significant on separate analysis of RTX-CSA and RTX-FK and after correction for arterial diameter, blood pressure, graft function, age, sex and smoking habits by stepwise multiple regression analysis. (See Table and Figure) Group RTX CTR MAP (mmHg) 103 ± 2* 86 ± 3 DC car (10-3/kPa) 17 ± 1* 26 ± 1 DC bra (10-3/kPa) 7 ± 1* 12 ± 1 MSNA (bursts/min) 36 ± 3* 16 ± 4 *p<0.05 vs. CTR. The results show that increased sympathetic nerve activity in RTX can adversely influence mechanical vessel wall properties of muscular type arteries. In contrast, the results failed to demonstrate an effect of MSNA on mechanical properties of elastic type arteries.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/S0895-7061(00)00685-3</doi></addata></record> |
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| ispartof | American journal of hypertension, 2000-04, Vol.13 (S2), p.195A-195A |
| issn | 0895-7061 1941-7225 1879-1905 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | arterial distensibility Renal transplantation sympathetic nervous system |
| title | B024: Increased muscle sympathetic nerve activity contributes to disturbed large artery distensibility in renal transplant patients |
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