A084: Spectral analysis of blood pressure variability before and after exercise during angiotensin antagonism
We evaluated the effects of tasosartan (TASO), a specific antagonist of AT1 receptors, on blood pressure (BP) variability before and after exercise. Twenty hypertensive patients (48 ± 2 years, 78 ± 3 kg, 28 ± 1 kg/m2, mean ± SEM) participated in this randomized, double-blind crossover, placebo-contr...
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| Veröffentlicht in: | American journal of hypertension 2000-04, Vol.13 (S2), p.142A-142A |
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| creator | Rhéaume, C. Karas, M. de Champlain, J. Lacourcière, Y. Cléroux, J. |
| description | We evaluated the effects of tasosartan (TASO), a specific antagonist of AT1 receptors, on blood pressure (BP) variability before and after exercise. Twenty hypertensive patients (48 ± 2 years, 78 ± 3 kg, 28 ± 1 kg/m2, mean ± SEM) participated in this randomized, double-blind crossover, placebo-controlled study. Each patient received TASO (100 mg/d) or placebo (PLAC) during two periods of two weeks separated by two weeks of wash out. Beat by beat systolic (SBP) and diastolic blood pressures (DBP) were measured by a photoplethysmographic device (Finapress) and recorded on a computer during 10 minutes before and after an exercise period of 30 minutes on a stationary bicycle at 50% of VO2max. Autonomic nervous system activity was evaluated by spectral analysis of SBP and DBP variability using the low frequency band (0.05–0.15 Hz, LF power, in ms2/Hz), to assess sympathetic activity and the high frequency band (0.15–0.4 Hz, HF power, ms2/Hz) to assess parasympathetic activity. The LF/HF ratio was taken as an index of sympathovagal balance. (See Table) Pre-exercise Post-exercise PLAC TASO PLAC TASO BP SBP 144 ± 4 132 ± 3*** 141 ± 3† 126 ± 3***,††† DBP 92 ± 2 87 ± 1*** 92 ± 1 84 ± 1***,† LF: SBP 24.1 ± 2.7 25.6 ± 2.9 21.6 ± 2.5 19.2 ± 2.4† DBP 34.7 ± 4.1 37.4 ± 4.3 32.0 ± 4.0 31.5 ± 3.7† HF: SBP 7.0 ± 1.3 9.1 ± 2.1 7.2 ± 1.4 5.5 ± 1.1† DBP 7.0 ± 1.1 7.9 ± 1.3 6.1 ± 1.0 4.9 ± 0.9† LF/HF: SBP 5.8 ± 1.4 4.9 ± 0.8 5.2 ± 1.3 5.3 ± 0.8 DBP 8.5 ± 2.8 6.2 ± 0.9 9.2 ± 2.7 8.8 ± 1.2† *P < 0.05, ***p < 0.001 vs PLAC; † |
| doi_str_mv | 10.1016/S0895-7061(00)00617-8 |
| format | Article |
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Twenty hypertensive patients (48 ± 2 years, 78 ± 3 kg, 28 ± 1 kg/m2, mean ± SEM) participated in this randomized, double-blind crossover, placebo-controlled study. Each patient received TASO (100 mg/d) or placebo (PLAC) during two periods of two weeks separated by two weeks of wash out. Beat by beat systolic (SBP) and diastolic blood pressures (DBP) were measured by a photoplethysmographic device (Finapress) and recorded on a computer during 10 minutes before and after an exercise period of 30 minutes on a stationary bicycle at 50% of VO2max. Autonomic nervous system activity was evaluated by spectral analysis of SBP and DBP variability using the low frequency band (0.05–0.15 Hz, LF power, in ms2/Hz), to assess sympathetic activity and the high frequency band (0.15–0.4 Hz, HF power, ms2/Hz) to assess parasympathetic activity. The LF/HF ratio was taken as an index of sympathovagal balance. (See Table) Pre-exercise Post-exercise PLAC TASO PLAC TASO BP SBP 144 ± 4 132 ± 3*** 141 ± 3† 126 ± 3***,††† DBP 92 ± 2 87 ± 1*** 92 ± 1 84 ± 1***,† LF: SBP 24.1 ± 2.7 25.6 ± 2.9 21.6 ± 2.5 19.2 ± 2.4† DBP 34.7 ± 4.1 37.4 ± 4.3 32.0 ± 4.0 31.5 ± 3.7† HF: SBP 7.0 ± 1.3 9.1 ± 2.1 7.2 ± 1.4 5.5 ± 1.1† DBP 7.0 ± 1.1 7.9 ± 1.3 6.1 ± 1.0 4.9 ± 0.9† LF/HF: SBP 5.8 ± 1.4 4.9 ± 0.8 5.2 ± 1.3 5.3 ± 0.8 DBP 8.5 ± 2.8 6.2 ± 0.9 9.2 ± 2.7 8.8 ± 1.2† *P < 0.05, ***p < 0.001 vs PLAC; †<0.05; †††<0.001 vs same treatment during pre-exercise evaluation (ANOVA). These results suggest that sympathetic and parasympathetic activity are decreased to different extents after exercise with TASO leading to an increased sympathovagal balance whereas no such change was found with placebo. A shift toward higher sympathetic vs parasympathetic balance may occur as a result of baroreflex activation due to greater reduction in BP after exercise with TASO compared to PLAC.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/S0895-7061(00)00617-8</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>angiotensin antagonism ; low and high frequency bands ; Spectral analysis ; systolic and diastolic blood pressure and exercise</subject><ispartof>American journal of hypertension, 2000-04, Vol.13 (S2), p.142A-142A</ispartof><rights>Copyright Nature Publishing Group Apr 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Rhéaume, C.</creatorcontrib><creatorcontrib>Karas, M.</creatorcontrib><creatorcontrib>de Champlain, J.</creatorcontrib><creatorcontrib>Lacourcière, Y.</creatorcontrib><creatorcontrib>Cléroux, J.</creatorcontrib><title>A084: Spectral analysis of blood pressure variability before and after exercise during angiotensin antagonism</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>We evaluated the effects of tasosartan (TASO), a specific antagonist of AT1 receptors, on blood pressure (BP) variability before and after exercise. Twenty hypertensive patients (48 ± 2 years, 78 ± 3 kg, 28 ± 1 kg/m2, mean ± SEM) participated in this randomized, double-blind crossover, placebo-controlled study. Each patient received TASO (100 mg/d) or placebo (PLAC) during two periods of two weeks separated by two weeks of wash out. Beat by beat systolic (SBP) and diastolic blood pressures (DBP) were measured by a photoplethysmographic device (Finapress) and recorded on a computer during 10 minutes before and after an exercise period of 30 minutes on a stationary bicycle at 50% of VO2max. Autonomic nervous system activity was evaluated by spectral analysis of SBP and DBP variability using the low frequency band (0.05–0.15 Hz, LF power, in ms2/Hz), to assess sympathetic activity and the high frequency band (0.15–0.4 Hz, HF power, ms2/Hz) to assess parasympathetic activity. The LF/HF ratio was taken as an index of sympathovagal balance. (See Table) Pre-exercise Post-exercise PLAC TASO PLAC TASO BP SBP 144 ± 4 132 ± 3*** 141 ± 3† 126 ± 3***,††† DBP 92 ± 2 87 ± 1*** 92 ± 1 84 ± 1***,† LF: SBP 24.1 ± 2.7 25.6 ± 2.9 21.6 ± 2.5 19.2 ± 2.4† DBP 34.7 ± 4.1 37.4 ± 4.3 32.0 ± 4.0 31.5 ± 3.7† HF: SBP 7.0 ± 1.3 9.1 ± 2.1 7.2 ± 1.4 5.5 ± 1.1† DBP 7.0 ± 1.1 7.9 ± 1.3 6.1 ± 1.0 4.9 ± 0.9† LF/HF: SBP 5.8 ± 1.4 4.9 ± 0.8 5.2 ± 1.3 5.3 ± 0.8 DBP 8.5 ± 2.8 6.2 ± 0.9 9.2 ± 2.7 8.8 ± 1.2† *P < 0.05, ***p < 0.001 vs PLAC; †<0.05; †††<0.001 vs same treatment during pre-exercise evaluation (ANOVA). These results suggest that sympathetic and parasympathetic activity are decreased to different extents after exercise with TASO leading to an increased sympathovagal balance whereas no such change was found with placebo. A shift toward higher sympathetic vs parasympathetic balance may occur as a result of baroreflex activation due to greater reduction in BP after exercise with TASO compared to PLAC.</description><subject>angiotensin antagonism</subject><subject>low and high frequency bands</subject><subject>Spectral analysis</subject><subject>systolic and diastolic blood pressure and exercise</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNo9j89LwzAcxYMoOKd_ghDwoofqN2l-1dvYdBMHHjZEvIS0TUdm19Skle2_tzDx9B7vfXjwELomcE-AiIcVqIwnEgS5BbiDQWWiTtCIZIwkklJ-ikb_yDm6iHELAEwIMkK7CSj2iFetLbpgamwaUx-ii9hXOK-9L3EbbIx9sPjHBGdyV7vugHNb-SEyTYlN1dmA7d6GwkWLyz64ZjM0G-c720TXDL4zG9-4uLtEZ5Wpo7360zFaPz-tp4tk-TZ_mU6WiRNCJhZUKnkGVAA1XNEMyoqygjFVlSQvKSdCppQaYgeyTIsSCAgGhsmsIkLRdIxujrNt8N-9jZ3e-j4Mz6ImkCrCOOFyoJIj5WJn97oNbmfCQZvwpYd9yfXi41Nn8xl5f01nWqW_shRqDg</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>Rhéaume, C.</creator><creator>Karas, M.</creator><creator>de Champlain, J.</creator><creator>Lacourcière, Y.</creator><creator>Cléroux, J.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200004</creationdate><title>A084: Spectral analysis of blood pressure variability before and after exercise during angiotensin antagonism</title><author>Rhéaume, C. ; Karas, M. ; de Champlain, J. ; Lacourcière, Y. ; Cléroux, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i667-e08375902602a58290df24c448fd1bd25167322a1ee08d3cd010640a479f16823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>angiotensin antagonism</topic><topic>low and high frequency bands</topic><topic>Spectral analysis</topic><topic>systolic and diastolic blood pressure and exercise</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhéaume, C.</creatorcontrib><creatorcontrib>Karas, M.</creatorcontrib><creatorcontrib>de Champlain, J.</creatorcontrib><creatorcontrib>Lacourcière, Y.</creatorcontrib><creatorcontrib>Cléroux, J.</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhéaume, C.</au><au>Karas, M.</au><au>de Champlain, J.</au><au>Lacourcière, Y.</au><au>Cléroux, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A084: Spectral analysis of blood pressure variability before and after exercise during angiotensin antagonism</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2000-04</date><risdate>2000</risdate><volume>13</volume><issue>S2</issue><spage>142A</spage><epage>142A</epage><pages>142A-142A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>We evaluated the effects of tasosartan (TASO), a specific antagonist of AT1 receptors, on blood pressure (BP) variability before and after exercise. Twenty hypertensive patients (48 ± 2 years, 78 ± 3 kg, 28 ± 1 kg/m2, mean ± SEM) participated in this randomized, double-blind crossover, placebo-controlled study. Each patient received TASO (100 mg/d) or placebo (PLAC) during two periods of two weeks separated by two weeks of wash out. Beat by beat systolic (SBP) and diastolic blood pressures (DBP) were measured by a photoplethysmographic device (Finapress) and recorded on a computer during 10 minutes before and after an exercise period of 30 minutes on a stationary bicycle at 50% of VO2max. Autonomic nervous system activity was evaluated by spectral analysis of SBP and DBP variability using the low frequency band (0.05–0.15 Hz, LF power, in ms2/Hz), to assess sympathetic activity and the high frequency band (0.15–0.4 Hz, HF power, ms2/Hz) to assess parasympathetic activity. The LF/HF ratio was taken as an index of sympathovagal balance. (See Table) Pre-exercise Post-exercise PLAC TASO PLAC TASO BP SBP 144 ± 4 132 ± 3*** 141 ± 3† 126 ± 3***,††† DBP 92 ± 2 87 ± 1*** 92 ± 1 84 ± 1***,† LF: SBP 24.1 ± 2.7 25.6 ± 2.9 21.6 ± 2.5 19.2 ± 2.4† DBP 34.7 ± 4.1 37.4 ± 4.3 32.0 ± 4.0 31.5 ± 3.7† HF: SBP 7.0 ± 1.3 9.1 ± 2.1 7.2 ± 1.4 5.5 ± 1.1† DBP 7.0 ± 1.1 7.9 ± 1.3 6.1 ± 1.0 4.9 ± 0.9† LF/HF: SBP 5.8 ± 1.4 4.9 ± 0.8 5.2 ± 1.3 5.3 ± 0.8 DBP 8.5 ± 2.8 6.2 ± 0.9 9.2 ± 2.7 8.8 ± 1.2† *P < 0.05, ***p < 0.001 vs PLAC; †<0.05; †††<0.001 vs same treatment during pre-exercise evaluation (ANOVA). These results suggest that sympathetic and parasympathetic activity are decreased to different extents after exercise with TASO leading to an increased sympathovagal balance whereas no such change was found with placebo. A shift toward higher sympathetic vs parasympathetic balance may occur as a result of baroreflex activation due to greater reduction in BP after exercise with TASO compared to PLAC.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/S0895-7061(00)00617-8</doi></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | angiotensin antagonism low and high frequency bands Spectral analysis systolic and diastolic blood pressure and exercise |
| title | A084: Spectral analysis of blood pressure variability before and after exercise during angiotensin antagonism |
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